margin involvement

margin involvement

The direct extension of a solid malignancy (e.g., colorectal carcinoma) to the margin of resection. In practice, margins are regarded as involved if a tumour is located ≤ 1 mm from the resection margin.
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In a similarly designed study by Chang et al, (8) greater than one-third of all punch excisions of melanocytic nevi with apparently negative margins on initial examination were found to have positive margin involvement upon through-block sectioning.
It constitutes a leap forward with respect to current and proposed diagnostics, allowing to diagnose and treat breast carcinoma margin involvement for the first time (i) intraoperatively (ii) at the single cell level (iii) over the entire surgical incision; in a (iv) simple, (v) inexpensive,(vi) biocompatible package; that can be (vii) routinely employed by surgeons without requiring (viii) added equipment or (ix) prolonged analysis.
Seven patients (39%) had no surgical margin involvement.
His histopathological report was a well differentiated squamous cell carcinoma with margin involvement.
4-6) In reality, the significance of proximal margin involvement by an appendiceal adenoma or a LAMN that is otherwise confined to the appendix is not clear and data to guide management of these patients are lacking.
3,4) Pai et al (4) evaluated a series of 116 patients with appendiceal mucinous neoplasms, including 1 who had extra-appendi Appendectomy Margin Involvement in LAMNs--Arnason et al ceal mucin and neoplastic epithelial cells in the right lower quadrant as well as tumor present at the surgical resection margin.
Margin involvement by low-grade appendiceal mucinous neoplasm (LAMN).
Univariate analysis showed that retrolaminar optic nerve invasion, optic nerve cut margin involvement, scleral invasion, undifferentiated tumor greater than 60%, and high pathologic stage were significant pathologic risk factors that could predict the occurrence of an event and were correlated with survival.
16-18) However, uniform agreement on the need for chemotherapy with the other forms of risk factors, such as massive choroidal invasion or retrolaminar invasion without cut margin involvement, has not yet been achieved.
Consequently, it has been difficult for pathologists to identify prostate cancers during gross examination and to sample tissues for microscopic examination of important prognostic information, such as the Gleason score, stage, extraprostatic extension, and resection margin involvement.
4,5,7-9) These partial sampling methods were able to reduce the number of paraffin blocks; however, they were at the expense of losing the important prognostic information, especially T stage, extraprostatic extension, and resection margin involvement status.