maprotiline hydrochloride

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ma·pro·ti·line hydrochloride (m

-pr

)

An antidepressant that is chemically similar to tricyclic antidepressants and that inhibits neuronal reuptake of norepinephrine.

maprotiline hydrochloride

[maprō′tilēn]

a tetracyclic antidepressant similar to the tricyclics.

indication It is prescribed for the treatment of depression.

contraindications It is used with caution in conditions in which anticholinergics are contraindicated, in seizure disorders, and in cardiovascular disorders. Concomitant administration of monoamine oxidase inhibitors, recent myocardial infarction, or known hypersensitivity to this drug prohibits its use.

adverse effects Among the more serious adverse effects are sedation and anticholinergic side effects. A variety of GI, cardiovascular, and neurologic reactions (including convulsions) may occur. Like the tricyclics, it is involved in many potential drug interactions.

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