maprotiline


Also found in: Wikipedia.

maprotiline

 [mah-pro´tĭ-lēn]
a tetracyclic antidepressant administered orally as the hydrochloride salt for relief of symptoms of depression. It acts by blocking the reuptake of norepinephrine at nerve terminals; unlike tricyclic antidepressants, it has no effect on serotoninergic transmission.

maprotiline

/ma·pro·ti·line/ (mah-pro´tĭ-lēn) a tetracyclic antidepressant with actions similar to those of the tricyclic antidepressants; used as the hydrochloride salt.

maprotiline

A tetracyclic antidepressant similar to tricyclic agents.
 
Indications
Major depression, bipolar disorder.

Adverse effects
Anticholinergic effects (e.g., dizziness, drowsiness, fatigue, dry mouth), orthostatic hypotension, sinus tachycardia or other arrhythmias, sexual dysfunction, rash, photosensitivity, confusion, seizures, liver toxicity, agranulocytosis, polyneuritis and other findings.

Special considerations
Should not be administered with MAOIs; may be toxic to the liver or kidneys; may cause seizures; may cause arrhythmias or heart failure.

maprotiline

Ludiomil® Neuropharmacology A tetracyclic antidepressant similar to tricyclic agents Indications Major depression, bipolar disorder. See Tricyclic antidepressant.
References in periodicals archive ?
Antidepressant drugs, including Tricyclic Antidepressant (TCAs), Selective serotonin reptake Inhibitors (SSRIs), Monoamine Oxidase Inhibitors (MAOIs), maprotiline, trazodone, Bupropion and venlafaxine.
Maprotiline hydrochloride tablets (Novartis, Beijing, China), Anafranil (clomipramine hydrochloride tablets, Novartis, Beijing, China), Seroxat (paroxetine hydrochloride tablets, SmithKline, Tianjin, China), Prozac (fluoxetine hydrochloride capsules, Patheon, Bourgoin-Jallieu, France), and Neurostan (extract of St.
A large, Canadian case-control study published in 2002 raised concerns of heightened cancer risk among patients prescribed certain tricyclic antidepressants (amoxapine, clomipramine, desipramine, doxepin, imipramine, and trimipramine) but not others (amitriptyline, maprotiline, nortriptyline, protriptyline) (Br.
in urine 36 Prothipendyl 2275 2618 41 Fluoxetine 4338 4278 Bromazepam 129 Maprotiline 352 349 50 Caffeine 191 Ketamine 1050 Bisacodyl 106 1750 58 Paracetamol 825 188 Diazepam 272 60 Amphetamine 55 68 Venlafaxine 5269 69 Prothipendyl 387 1883 76 Sertraline 4642 4640 4685 81 Metformine 6510 Dobutamine 1273 2980 83 Midazolam 296 90 Maprotiline 348 352 349 Sample Substance Name of detected compound no.
Antidepressants that have been shown to have the highest overall incidence of contributing to seizure development are clomipramine, bupropion, and maprotiline (Koppel, 2004).
Patient Age [greater than Antidepressant or equal to]65 <65 Sertraline 25 50 Paroxetine 10 20 Citalopram * 20 20 Fluoxetine 10 20 Fluvoxamine * 100 100 Amitriptyline NR 50 Desipramine 25 100 Doxepin 30 75 Imipramine 30 75 Nortriptyline 30 75 Protriptyline 15 15 Trimipramine 50 75 Clomipramine 75 75 Trazodone 25 150 Buproprion 50 200 Phenelzine 45 45 Tranylcypromine 20 20 Maprotiline 25 75 Nefazodone 100 200 Venlafaxine 50 75 Mirtazapine 15 15 Amoxapine 50 100 * These antidepressants were not addressed in 1997 Department of Veterans Affairs depression guidelines; minimum daily dosage for these medications derived from expert consensus.
O-T prolongation and torsades de pointes ventricular tachycardia produced by the tetracyclic antidepressant agent maprotiline.
Similarly, we classified the tricyclic amines (TCAs), trazodone, and maprotiline as older antidepressants: selective serotonin reuptake inhibitors (SSRIs), and other trade name only antidepressants (e.
xx Aventyl, Budeprion SR, bupropion, Celexa, clomipramine, desipramine, Desyrel, Effexor, Effexor XR, Elavil, Emitrip, fluoxetine, fluvoxamine maleate, imipramine, Lexapro, Ludiomil, Luvox, maprotiline, mirtazapine, nefazodone, Norpramin, nortriptyline, Pamelor, paroxetine, Paxil, Paxil CR, Pexeva, Prozac, Prozac Weekly, Remeron, Serzone, Surmontil, Tofranil, Tofranil-PM, Trazodone, Vivactil, Wellbutrin, Wellbutrin SR, Wellbutrin XL, Zoloft Diabetes 250.
Brofaromine versus lithium addition to maportiline: A double-blind study in maprotiline refractory depressed outclients.
Heterocyclics include bupropion (Wellbutrin, Wellbutrin SR, Zyban), venlafaxine (Effexor), trazodone (Desyrel, Trazon, Trialodine), mirtazapine (N10A, Remeron), and maprotiline (Ludiomil).