Mantle zone | definition of mantle zone by Medical dictionary
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Related to mantle zone: Mantle Zone Lymphoma
2. a layer of small B lymphocytes surrounding the paler-staining germinal centers of lymphoid follicles.
1. an enveloping structure or layer, especially the brain mantle, or pallium.
an outer region surrounding germinal centers in the cortex of lymph nodes.
References in periodicals archive
lymphoma: a clinicopathologic study of 22 cases.
In addition, the absence of proliferation centers and the distribution of neoplastic cells in the mantle zones
surrounding germinal centers made this diagnosis highly unlikely.
The CD20+ mantle zone
lymphocytes are expanded and arranged in a distinctive concentric "onion-skin" fashion (Figure 2).
Neoplastic follicles are poorly defined; they lack a mantle zone
and polarization; they have few mitotic figures; and they tend to lack tingible-body macrophages.