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A group of enzymes that catalyze the hydrolysis of terminal, nonreducing d-mannose residues of mannosides (particularly in glycoproteins and glycolipids); α-mannosidases act on α-d-mannosides whereas β-mannosidases act on β-d-mannosides; a deficiency of α-mannosidases is associated with mannosidosis.
References in periodicals archive ?
2011) A complex of Pdi1p and the mannosidase Htm1p initiates clearance of unfolded glycoproteins from the endoplasmic reticulum.
Although in this case most of the mannosidase recovered (88%) was readily soluble with little extra enzyme activity (12%) released on triton treatment.
The scientists modified the yeast by first eliminating endogenous yeast glycosylation pathways, while sequentially engineering into the organism five active eukaryotic proteins, including mannosidases I & II, N-acetylglucosaminyl transferases I & II and UDP-N-acetylglucosamine transporter.