mannose-binding protein

mannose-binding protein

a protein involved in innate immunity that can bind mannosylated microorganisms and activate the complement pathway.

mannose-binding protein

A protein encoded by MASP1 on chromosome 3q27-q28, and found in the serum and liver, which mediates innate antimicrobial defence by binding to specific cell surface high mannose oligosaccharides of various bacteria, fungi and possibly also viruses (e.g., HIV), killing them by complement-mediated cell lysis or opsonisation.

man·nose-bind·ing pro·tein

(man'ōs bīnd'ing prō'tēn)
A protein involved in innate immunity that can bind mannosylated microorganisms and activate the complement pathway.
References in periodicals archive ?
Assessment of measuring circulating levels of interleukin-6, interleukin-8, C-reactive protein, soluble Fc gamma receptor type III, and mannose-binding protein in febrile children with cancer and neutropenia.
Mannose-binding protein B allele confers protection against tuberculous meningitis.
Structure of a C-type mannose-binding protein complexed with an oligosaccharide.
Activation of the classical complement pathway by mannose-binding protein in association with a novel C1s-like serine protease.
Engineering galactose-binding activity into a C-type mannose-binding protein.
Structure of a selectin-like mutant of mannose-binding protein complexed with sialylated and sulfated Lewis(x) oligosaccharides.
Molecular defects in variant forms of mannose-binding protein associated with immunodefciency.
RANTES, MIP-1), human leukocyte antigen haplotype, mannose-binding protein, and tumor necrosis factor alpha, C4, and TAP polymorphism (2-4).
A human serum mannose-binding protein inhibits in vitro infection by the human immunodeficiency virus.
Analytical evaluation of particle-enhanced immunonephelometric assays for C-reactive protein, serum amyloid A and mannose-binding protein in human serum.
Analytical evaluation of particle-enhanced immunonephelometric assays for Creactive protein, serum amyloid A and mannose-binding protein in human serum.

Full browser ?