Design of neo-glycoconjugates that target the mannose
receptor and enhance TLR-independent cross-presentation and Th1 polarization," European Journal of Immunology, vol.
Fundamentally, most bacterial polysaccharides are composed of glucose, galactose and mannose
in the molecule.
The study demonstrates that radiolabeled dextran cysteamine mannose
might prove a successful radiopharmaceutical for sentinel lymph node detection in future clinical applications.
The lectins used were: (1) Concanavalin-A (Con-A) to recognize glucose (Glc), (2) Glanthus nivalis (GNL) for mannose
([alpha] 1-3) mannose
(Man-Man), (3) Lens culinaris agglutinin (LCA) for [alpha]-mannose
(Man) and [alpha]-glucose (Glc), (4) Lotus tetranoglobus agglutinin (LTA) for fucose (Fuc), (5) Badeiraea simplicifolia-I (BS-I) for galactose (Gal), (6) Griffonia simplicifolia (GSL II) for N-acetyl-glucosamine (N-AcGlc), and (7) Dolichos biflorus agglutinin (DBA) for N-acetyl-galactosamine (N-AcGal) at concentrations of 10 mg [mL.
But "in reality, almost all the mannose
is metabolized before ever reaching the urine," he said.
Studies related to immune function have focused on a number of candidate genes such as, mannose
binding lectin (MBL2), intedeukin 1-alpha, (ILIA), storkhead box 1 (STOX1), and cytoxic T lymphocyte associated 4 (CTLA4) with variable results (3, 4).
1)* maculata Mucus + Carbohydrates Species Glucose Mannose
LP is activated by binding of mannose
binding lectin (MBL) or ficolin to pathogen-associated molecular patterns (PAMPs) on the surface of microbes.
In vivo recognition of mannosylated proteins by hepatic mannose
receptors and mannan-binding protein.
The lamprey MBL binds to mannose
on the surface of the pathogen Aeromonas salmonicida.
Antisense inhibition of the GMPase led to a significant reduction of the mannose
content in leaf cell walls, indicaing that GDP-D-mannose
is the sole precursor for the incorporation of mannose
into hemicellulose (Keller et al.
The present data suggested that lipid vesicle-trapped herbal antioxidant quercetin and CDP-Choline may not only be effective in combating the cerebral ischemic reperfusion oxidative damage but also to prevent cerebral edema development both in young and old animals) The mechanism how quercetin and CDP-Choline in mannosylated liposome exerts a complete protection against ischemia-reperfusion mediated cerebral oxidative damage in young and aged rats is not fully clear) Although expression of the mannose
mannosylated liposomes were successfully incorporated into mouse brain)