mannan-binding lectin


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mannan-binding lectin (MBL),

a circulating plasma, acute phase protein of hepatic origins that plays an important role in the innate immune response to infection, because it binds to carbohydrates on bacteria, and subsequently activates the complement pathway. It is a key feature in the lectin pathway of complement activation. Deficiency of MBL can lead to recurrent infections, particularly in childhood. MBL is polymorphic in the population and a deficiency of MBL is likely due to a defective protein, which cannot form oligomers and is also associated with some autoimmune diseases such as rheumatoid arthritis.
References in periodicals archive ?
Adult mallard ducks (Arias platyrhynchos) were orally dosed with bunker C fuel oil for 5 days, and 5 different inflammatory markers (haptoglobin, mannan-binding lectin, ceruloplasmin, unsaturated iron-binding capacity, and plasma iron) were measured in blood plasma before and 8, 24, 48, and 72 hours after exposure.
Different molecular events results in low protein levels of mannan-binding lectin in populations from Southeast Africa and South America.
Detection and characterization of a mannan-binding lectin from mosquito, Anopheles stephensi (Liston).
Madsen HO, Satz ML, Hogh B, Svcigaard A, Garred R Different molecular events result in low protein level of mannan-binding lectin in population from southeast Africa and South America.
On the other hand, mannan-binding lectin (MBL) deficiency has been related to IgG subclass deficiency in pediatric patients with increased susceptibility to infections (4).
Nasdaq: ENZN) and the Danish biotech company, NatImmune A/S today announced that they have entered into a license agreement for NatImmune's lead development product, recombinant human Mannan-Binding Lectin (rhMBL), a protein therapeutic being developed for the prevention of severe infections in MBL-deficient individuals undergoing chemotherapy.
Different molecular events result in low protein levels of mannan-binding lectin in populations from southeast Africa and south America.