mammaglobin-1

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mammaglobin-1

A 10-kD breast-specific glycoprotein encoded by SCGB2A2 on chromosome 11q13. It is overexpressed in ≥ 25% of primary breast cancer, and may be a diagnostic marker for managing breast cancer.
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24) The most specific markers for a breast primary are GATA3, mammaglobin, and GCDFP15, for which secondary tumors are consistently negative.
Subsequent staining for breast carcinoma marker mammaglobin was negative and evidence of ductal carcinoma in situ was absent.
Cytokeratin-19 and mammaglobin gene expression in circulating tumor cells from metastatic breast cancer patients enrolled in North Central Cancer Treatment Group trials, N0234/336/436/437.
They are also positive for vimentin, S-100, mammaglobin, GCDFP-15, MUC1, GATA-binding protein 3, adipophilin, a-amylase, DOG-1, SOX-10, and p63 [1,2].
Immunohistochemistry was negative for thyroglobulin (Tg), mammaglobin, and GCDFP-15 and positive for WT1 protein, suggesting that the primary tumor was of gynecologic origin.
Being able to target mammaglobin is exciting because it is expressed broadly in up to 80 percent of breast cancers, but not at meaningful levels in other tissues," said breast cancer surgeon and senior author William E.
Diagnostic utility of mammaglobin and GCDFP-15 in the identification of metastatic breast carcinoma in fluid specimens.
Emergent molecular techniques for intra-operative sentinel node analysis as exemplified by the GeneSearch[TM] BLN Assay (Veridex, LLC) and the OSNA assay (Sysmex, Kobe, Japan) detect cytokeratin 19, and also in the case of GeneSearch, mammaglobin in sentinel nodes to determine if metastases are present.
The University of North Tees research programme aims to find if raised levels of mammaglobin in the blood is a sign of an extremely early stage of breast cancer.
The carcinoma was positive for cytokeratin (CK) 7 (Figure 1, G), CK18, mammaglobin (Figure 1, H), S100 protein (S100) (Figure 1, I), and signal transducer and activator of transcription 5a (STAT5a); focally positive for p63 protein (p63); and negative for gross cystic disease fluid protein 15 (GCDFP-15), discovered on GIST-1 (DOG1), smooth muscle actin (SMA), calponin, and estrogen receptor/ progesterone receptor (ER/PR).
More recently, differential mRNA expression of cytokeratin 19 (CK19) and mammaglobin in breast epithelial cells versus lymphoid cells has been used to develop a real-time RT-PCR assay (GeneSearch[TM] BLN Assay, Veridex, LLC, Warren, NJ) to detect sentinel lymph node metastasis intraoperatively by assessing the homogenate of the nodal tissue [27-31].
A CT-guided biopsy of the pleural nodule revealed adenocarcinoma (Figure 9, A) positive for GATA-binding protein 3 (GATA3) (Figure 9, B), progesterone receptor (PR) (Figure 9, C), estrogen receptor (ER) (Figure 9, D), mammaglobin (Figure 9, E), and gross cystic disease fluid protein 15 (GCDFP-15) (focal), but negative for TTF-1 (Figure 9, F) and p40.