malondialdehyde-modified LDL

malondialdehyde-modified LDL

A low-density lipoprotein, which is chemically modified in vivo, thought to reflect naturally occurring oxidation of LDL and serve as a surrogate marker for significant atherosclerosis; it is thus useful as a biochemical marker of coronary artery disease.
References in periodicals archive ?
Beneficial effects of grape seed extract on malondialdehyde-modified LDL.
Oxidized LDL and malondialdehyde-modified LDL in patients with acute coronary syndromes and stable coronary artery disease.
However, assays based on sandwich ELISAs have been developed mainly for oxLDL and its isoform, malondialdehyde-modified LDL (MDA-LDL), by several groups (15,32,33,48,49).
We previously reported that malondialdehyde-modified LDL (MDA-LDL) is distributed to small dense LDL fractions by density gradient ultracentrifugation (7).
Malondialdehyde-modified LDL has been shown to stimulate formation of autoantibodies, and immune complexes of LDL aggregates are efficiently internalized by macrophages via Fc receptors, further promoting cholesterol accumulation.