malignant osteoporosis

malignant osteoporosis

Osteolysis secondary to infiltration by a malignancy, often accompanied by pain. 80% of bone metastases arise from cancer of breast, kidney, lung, prostate and thyroid; most weaken the bony trabeculae, except prostate cancer, which is often osteoblastic. 70% of bone metastases involve the axial skeleton; the remainder affect the proximal appendicular skeleton.
 
Lab
Increased acid phosphatase; if extensive, hypercalcaemia.
 
Management
Excise primary malignancy, fix unstable bone; radiation therapy is effective in most cases.

malignant osteoporosis

Osteolysis 2º to infiltration by CA, often accompanied by pain; 80% of bone metastases arise from CA of breast, kidney, lung, prostate, thyroid; most weaken the bony trabeculae, with the exception of prostate CA, which is often osteoblastic; 70% of bone metastases involve the axial skeleton; the remainder affect the proximal appendicular skeleton Lab ↑ Acid phosphatase, if extensive, hypercalcemia Treatment Remove 1º carcinoma, RT–effective in most cases and fixation of unstable bone. See Hypercalcemia of malignancy.
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