malignant osteoporosis

malignant osteoporosis

Osteolysis 2º to infiltration by CA, often accompanied by pain; 80% of bone metastases arise from CA of breast, kidney, lung, prostate, thyroid; most weaken the bony trabeculae, with the exception of prostate CA, which is often osteoblastic; 70% of bone metastases involve the axial skeleton; the remainder affect the proximal appendicular skeleton Lab ↑ Acid phosphatase, if extensive, hypercalcemia Treatment Remove 1º carcinoma, RT–effective in most cases and fixation of unstable bone. See Hypercalcemia of malignancy.