malignant mimic

malignant mimic

A generic term for a non-malignant lesion with an aggressive, malignant appearance.

Endoscopic lesions mimicking malignancy include “ragged”, well-circumscribed ulcers that histologically appear in an amorphous eosinophilic background, with sheets of closely packed acini, cells with swollen granular cytoplasm, variably-sized, often hyperchromatic nuclei, mitotic activity and a lesion that fades into benign regenerative mucosa.

Other endoscopic malignant mimics seen in the oesophagus, stomach and rectum consist of fibrinopurulent exudate, which covers aggregates of bizarre cells with variable amounts of granular cytoplasm, hyperchromatic pleomorphic nuclei. 

A lesion that grossly or microscopically mimics malignancy, which may be induced by inflammation, radiation therapy, chemotherapy, and evoke cytologic features of malignant lesions.
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Once again, it is the lack of significant nuclear pleomorphism, cytologic atypia, and abnormal mitoses that most clearly separates IMT from its malignant mimics.
The main factor distinguishing IMT from its malignant mimics is minimal cytologic atypia with a lack of nuclear hyperchromasia and the absence of abnormal mitoses.

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