malignant fibrous histiocytoma


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ma·lig·nant fi·brous his·ti·o·cy·to·ma

a sarcoma of variable malignant potential, occurring most often in the extremities and retroperitoneum; often recurs locally after resection, less often metastasizes; shows partial fibroblastic and histiocytic differentiation with a variable storiform pattern, myxoid areas, and giant cells.

malignant fibrous histiocytoma

A malignant tumour consisting of mitotically active spindled cells arranged in a storiform pattern. Malignant fibrous histiocytoma is no longer considered an entity a sui generis, given that many MFHs proved to be melanomas, poorly-differentiated carcinomas and lymphomas when examined by immunohistochemistry.

Reclassification of MFH types
• Angiomatoid type malignant fibrous histiocytoma—now Angiomatoid fibrous histiocytoma.
• Inflammatory malignant fibrous histiocytoma—now Inflammatory de-differentiated liposarcoma.
• Giant cell malignant fibrous histiocytoma, high grade—now Giant cell-rich extraskeletal osteosarcoma.
• Giant cell malignant fibrous histiocytoma, low grade—now Giant cell tumour of soft tissue.
• Malignant fibrous histiocytoma, myxoid type—now Myxofibrosarcoma.

malignant fibrous histiocytoma

A pleomorphic mesenchymal malignancy of older adults, which affects deep soft tissues–involving muscle 60% or fascia 20% of the lower–50% and upper–20% extremities, retroperitoneum 15% and abdominal cavity; MFH metastasizes to the lung 80%, lymph nodes 30%, liver, bone DiffDx Sarcomas, pleomorphic or primitive carcinoma, bizarre melanoma Prognosis 40-65% of tumors recur; 25-50% metastasize

ma·lig·nant fi·brous his·ti·o·cy·to·ma

(mă-lig'nănt fī'brŭs his'tē-ō-sī-tō'mă)
A deeply situated tumor, especially on the extremities of adults, frequently recurring after surgery and metastasizing to the lungs; shows partial fibroblastic and histiocytic differentiation with a variable storiform pattern, myxoid areas, and giant cells.

malignant

tending to become progressively worse and to result in death; having the properties of anaplasia, invasiveness and metastasis; said of tumors.

malignant aphtha
see contagious ecthyma.
malignant carbuncle
a form of anthrax in humans.
malignant catarrhal fever (MCF)
an acute highly infectious, fatal herpesvirus disease of cattle, farmed deer and occasionally pigs characterized by an erosive stomatitis and gastroenteritis, erosions on the mucosa of the upper respiratory tract, keratoconjunctivitis, encephalitis, and lymphadenopathy. There are at least two viruses involved. A wildebeest-associated form of the disease is caused by alcephaline herpesvirus 1. It occurs in most African countries in cattle which co-mingle with clinically normal wildebeest and hartebeest. It is epizootic and seasonal. It can also occur in zoological gardens in other countries. Sheep-associated MCF is caused by a poorly characterized virus, presumably ovine herpesvirus 2 (OvHV-2). Cases mostly occur when cattle have had contact with lambing ewes and usually start 1-2 months later. Goats can also act as a source of OvHV-2 infection for cattle. Cases without apparent or recent exposure to sheep do occur but are uncommon. Called also bovine malignant catarrh.
malignant edema
an acute infection of wounds by Clostridium septicum, C. chauvoei, C. perfringens, C. sordellii or C. novyi. The inflammation causes severe swelling and discoloration of skin and exposed tissues. There may be local subcutaneous emphysema and a frothy exudate, depending on the identity of the invading organism. There is a high fever and a profound toxemia; death follows within a few hours if treatment is not provided. Special occurrences are when a large number of animals are affected at one time. These include involvement of the vulva in recently lambed ewes, of shearing or docking wounds, and of the umbilicus or eyes of recently born lambs.
malignant fibrous histiocytoma
a rare aggressive tumor of dogs and cats; composed of densely packed fibroblasts and histiocytes.
malignant head catarrh
see malignant catarrhal fever.
malignant histiocytosis
see malignant histiocytosis.
malignant hyperthermia
see malignant hyperthermia, porcine stress syndrome.
malignant lymphoma
malignant pustule
see malignant carbuncle (above).
malignant theileriasis
theileriasis caused by Theileria hirci.
References in periodicals archive ?
Malignant fibrous histiocytoma (MFH) is one of the most common soft tissue sarcoma in adults but is rare in hand.
Malignant fibrous histiocytoma originating in the mediastinum: Report of a case.
Primary malignant fibrous histiocytoma of the spleen with spontaneous rupture: a case report and literature review.
The primary malignant fibrous histiocytomas (MFH) of the kidney are rarely seen malignant neoplasms of the kidney.
The diagnosis of malignant fibrous histiocytoma was made provisionally and the patient was attached to services of a regional cancer center where the diagnosis was confirmed and patient underwent multimodality management including excision of tumor, chest wall reconstruction and postoperative radiation therapy.
H-, K-, and N-ras gene mutation in atypical fibroxanthoma and malignant fibrous histiocytoma.
The tumor cells in malignant fibrous histiocytoma showed cytoplasmic immunoreactivity for vimentin [Figure 3b] with a Ki-67 labeling index of 30.
Only a few cases of malignant fibrous histiocytoma of the vocal fold have been previously reported in the literature.
Malignant fibrous histiocytoma (MFH) is synonymous with high-grade undifferentiated pleomorphic sarcoma and essentially represents a diagnosis of exclusion.

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