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ma·late de·hy·dro·gen·ase (MD),
an enzyme that, using either NAD+ or NADP+, catalyzes the dehydrogenation of malate to oxaloacetate or its decarboxylation to pyruvate and CO2. At least six malate dehydrogenases are known, distinguished by their products, use of NAD+ or NADP+, and specificity of substrate (one acts on d-malate, the rest act on l-malate); one of these proteins is an enzyme in the tricarboxylic acid cycle.
malic enzyme(1) Malate dehydrogenase (oxaloacetate-decarboxylating), EC 184.108.40.206.
(2) Malate dehydrogenase (decarboxylating), EC 220.127.116.11.
(3) Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+), EC 18.104.22.168.
an adaptive enzyme involved in lipogenesis. Catalyses the irreversible conversion of malate to pyruvate + CO2 in the cytosol. Called also the NADP-linked malate dehydrogenase.