malic enzyme


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ma·late de·hy·dro·gen·ase (MD),

an enzyme that, using either NAD+ or NADP+, catalyzes the dehydrogenation of malate to oxaloacetate or its decarboxylation to pyruvate and CO2. At least six malate dehydrogenases are known, distinguished by their products, use of NAD+ or NADP+, and specificity of substrate (one acts on d-malate, the rest act on l-malate); one of these proteins is an enzyme in the tricarboxylic acid cycle.

malic enzyme

(1) Malate dehydrogenase (oxaloacetate-decarboxylating), EC 1.1.1.38.
(2) Malate dehydrogenase (decarboxylating), EC 1.1.1.39.
(3) Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+), EC 1.1.1.40.

malic enzyme

an adaptive enzyme involved in lipogenesis. Catalyses the irreversible conversion of malate to pyruvate + CO2 in the cytosol. Called also the NADP-linked malate dehydrogenase.
References in periodicals archive ?
Aberrant chloroplasts in transgenic rice plants expressing a high level of maize NADP-dependent malic enzyme.
Hormonal regulation of malic enzyme and glucose-6-phosphate dehydrogenase in brown adipose tissue.
The activities of lactate dehydrogenase (LDH) fatty acid synthase (FAS) malic enzyme (ME) and glucose-6-phosphate dehydrogenase (G6-PDH) were determined in the LM of pigs.
Effects of methotrexate (MTX) on NAD(P)+ dehydrogenases of HeLa cells: malic enzymes, 2-oxoluterate and isocitrate dehydrogenases.
This result might also be due to the low respiration activity of these fruits, since low respiration activity reduced the consumption of malic acid by the activity of the malic enzyme in the tricarboxylic acid cycle (GOODENOUGH et al.
166) When added to thyroid T3, it has proven to be helpful in activation of the malic enzyme gene transcription inside the mitochondria.
Two hundred and sixty-one accessions of the genus Capsicum were obtained from the Colombian Amazonian germplasm bank at Amazonian Institute of Scientific Research (Sinchi) and were evaluated with five polymorphic enzymatic systems, including esterase (EST), peroxidase (PRX), 6-phosphogluconate dehydrogenase (6-PGDH), aspartate amino transferase (GOT), and malic enzyme (ME).
lamblia genes encoding short Fe-hydrogenase, malic enzyme, alcohol dehydrogenase E (ADHE), and ferredoxin 1 (entamoebas only) (Rosenthal et al.
The tested enzymes were aconitase (ACO), acid phosphatase (ACP), alcohol dehydrogenase (ADH), adenylate kinase (AK), arginine aminopeptidase (AMP), diaphorase (DIA), endopetidase (EP), esterase (EST), fructose-1,6-diphosphatase (FDP), glutamate dehydrogenase (GDH), glutamate oxaloacetate transaminase (GOT), hexokinase (HK), isocitrate dehydrogenase (ICD), leucine aminopeptidase (LAP), malate dehydrogenase (MDH), malic enzyme (ME), peptidase with leucyl-alanine (PEP-LA), 6-phosphogluconate dehydrogenase (PGD), phosphoglucoisomerase (GPI), and shikimate dehydrogenase (SKDH) (Siciliano and Shaw, 1976; Vallejos, 1983; Van Geyt and Smed, 1984; Acquaah, 1992).
Another NADPH-producing enzyme in larvae, malic enzyme (EC 1.
Effect of Sulfhydryl Reagents on the Activity of Malic Enzyme (E.