malate dehydrogenase


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ma·late de·hy·dro·gen·ase (MD),

an enzyme that, using either NAD+ or NADP+, catalyzes the dehydrogenation of malate to oxaloacetate or its decarboxylation to pyruvate and CO2. At least six malate dehydrogenases are known, distinguished by their products, use of NAD+ or NADP+, and specificity of substrate (one acts on d-malate, the rest act on l-malate); one of these proteins is an enzyme in the tricarboxylic acid cycle.

malate dehydrogenase

An oxidoreductase (EC 1.1.1.37) in mitochondria and the cytosol that catalyses the reversible NAD+/NADH reaction in the presence of S-malate, yielding oxaloacetate, a step in the citric acid cycle. Malate dehydrogenase is increased in myocardial infarction, hepatocellular necrosis, megaloblastic anaemia, and cancer.

mal·ate de·hy·dro·gen·ase

(mal'āt dē-hī'drō-jĕ-nās)
Any enzyme that catalyzes the dehydrogenation of malate to oxaloacetate. At least six are known; one is an enzyme in the tricarboxylic acid cycle.
References in periodicals archive ?
Isozyme analysis: In this study, polymorphism among parental lines of two F1 hybrids Shaktiman-1 [(CML 142 x CML 150) x CML186] and Shaktiman-2 (CML 176 x CML186) with respect to the esterase (EST), alcohol dehydrogenase (ADH), malate dehydrogenase (MDH) and acid phosphatase (ACP) was analyzed.
203 MyHC, myosin heavy-chain; LM, longissimus muscle; CK, creatine kinase; LDH, lactate dehydrogenase; SDH, succinate dehydrogenase; MDH, malate dehydrogenase.
Malate dehydrogenase, lipoprotein lipase, hepatic lipase and total lipase activities were measured colorimetry (Huaying Biotechnology and Science Inc.
Bands were revealed for the enzyme systems esterase (EST), according to Scandalios (1969), alcohol dehydrogenase (ADH), phosphoglucose isomerase (PGI), malate dehydrogenase (MDH) and malic enzyme (ME), described by Alfenas (1991), and alpha amylase ([alpha] - AMY), according to Alfenas (1998).
Four progeny rows, from experiments designed to test for recombination or allelism at the k2 (tan saddle) locus, y20 (yellow foliage) locus, or the Mdh1-n (mitochondrial malate dehydrogenase one null) locus, had both fertile and sterile plants (Chen and Palmer, 1996b, 1998b).
neomexicanus also has been documented through allozyme electrophoretic analyses of several populations in New Mexico; Parker and Selander (1984) found only two clones based upon a malate dehydrogenase locus among 112 specimens from seven localities and Cole et al.
Five proteins that are differentially expressed during differentiation were associated with glucose metabolism: Fructose-biphosphate aldolase A (aldolase A), Alphaenolase (NNE), Malate dehydrogenase (MDH), L-lactate dehydrogenase (LDH) and Glyceraldehyde-3-phosphate dehydrogensae (GAPDH).
The gels were stained for eight enzymes including aspartate aminotransferase (Weeden, 1984), aconitase (Cardy and Beversdorf, 1984), leucine aminopeptidase (Wendel and Weeden, 1989), malate dehydrogenase, phosphogluconate dehydrogenase, phosphoglucoisomerase, shikimate dehydrogenase, and triose phosphate isomerase.
The sequences for phosphoenolpyruvate carboxykinase (PEPCK), malate dehydrogenase (MD), and fumarate reductase (FR) were also obtained.