malariotherapy

ther·a·peu·tic ma·lar·i·a

intentionally induced malaria, formerly used against neurosyphilis and certain other paralytic diseases.
Synonym(s): malariotherapy

malariotherapy

The intentional inoculation of a patient with “benign” tertian malaria (Plasmodium vivax), a modality used in the pre-antibiotic era for treating neurosyphilis.

The data from uncontrolled studies suggest that there was little, if any, effect on the underlying syphilis, despite the nonspecific immune reaction with fever and secretion of TNF and IL-1, as the reports of success were largely clinical without laboratory confirmation. While it was thought that patients with neuroborreliosis (advanced Lyme disease) might respond to malariotherapy, it may complicate or exacerbate an already poor clinical situation (e.g., for Lyme disease) or be associated with clinical malaria.

ther·a·peu·tic ma·lar·i·a

(thār'ă-pyū'tik mă-lar'ē-ă)
Intentionally induced malaria, formerly used against neurosyphilis and certain other paralytic diseases.
Synonym(s): malariotherapy.

malariotherapy

(mă-lār-ē-ō-thĕr′ă-pē)
An obsolete method of treating syphilis of the central nervous system by injecting malarial organisms into the body. The organisms produce hyperthermia, which is then terminated by administration of an antimalarial.
References in periodicals archive ?
This incongruence is discussed and the possibility of an ecological malariotherapy as an influencing factor on the low hospital prevalence of general paresis is proposed.
Chinese Coolies in Peru; Psychiatric Disorders; General Paresis of the Insane; Ecological Malariotherapy.
A large body of historical data exists from the deliberate laboratory infection of 2 populations: 1) patients receiving malariotherapy (intentionally induced malaria) for neurosyphilis and related disorders; and 2) healthy prisoners who participated in malaria drug testing trials.
Multivariate models were used to overcome limitations of Kaplan-Meier analyses by allowing for adjustment for the effect of malariotherapy and by producing hazard ratios (HRs) to gauge the strength of association.
10) Baratz blasts Wulsin: malariotherapy compared to Tuskegee experiments.
Malariotherapy is basically safe for HIV infection and it improves some immunological parameters of HIV positive patients (127) resulting in an increased CD4 count (128).
None had a history of blood transfusions, tattoos, malariotherapy for Lyme disease, recent injecting-drug use, or previous malaria infection.
vivax has reportedly conferred partial resistance to induced infection during malariotherapy (2).
In December 1990, the Texas Department of Health (TDH) was contacted by a man who had recently moved from the northeastern United States and who was considering malariotherapy for Lyme disease (LD).
TDH personnel discouraged the man from attempting malariotherapy, emphasizing previously published warnings [1].
Other risk factors such as needle-sharing, malariotherapy, or organ transplants were discarded.
The precedent for this approach is the obsolete practice of malariotherapy for the treatment of neurosyphilis, which was widely used in the preantibiotic era [8].