malariotherapy

ther·a·peu·tic ma·lar·i·a

intentionally induced malaria, formerly used against neurosyphilis and certain other paralytic diseases.
Synonym(s): malariotherapy

malariotherapy

The intentional inoculation of a patient with “benign” tertian malaria (Plasmodium vivax), a modality used in the pre-antibiotic era for treating neurosyphilis.

The data from uncontrolled studies suggest that there was little, if any, effect on the underlying syphilis, despite the nonspecific immune reaction with fever and secretion of TNF and IL-1, as the reports of success were largely clinical without laboratory confirmation. While it was thought that patients with neuroborreliosis (advanced Lyme disease) might respond to malariotherapy, it may complicate or exacerbate an already poor clinical situation (e.g., for Lyme disease) or be associated with clinical malaria.

ther·a·peu·tic ma·lar·i·a

(thār'ă-pyū'tik mă-lar'ē-ă)
Intentionally induced malaria, formerly used against neurosyphilis and certain other paralytic diseases.
Synonym(s): malariotherapy.

malariotherapy

(mă-lār-ē-ō-thĕr′ă-pē)
An obsolete method of treating syphilis of the central nervous system by injecting malarial organisms into the body. The organisms produce hyperthermia, which is then terminated by administration of an antimalarial.
References in periodicals archive ?
A large body of historical data exists from the deliberate laboratory infection of 2 populations: 1) patients receiving malariotherapy (intentionally induced malaria) for neurosyphilis and related disorders; and 2) healthy prisoners who participated in malaria drug testing trials.
Multivariate models were used to overcome limitations of Kaplan-Meier analyses by allowing for adjustment for the effect of malariotherapy and by producing hazard ratios (HRs) to gauge the strength of association.
Malariotherapy treatments initially used a range of local strains from the United Kingdom, the Netherlands, and the United States, but these were quickly replaced with the Madagascar strain and others, which exhibited shorter incubation periods and more reliably produced infections (24).
Figure 1, panels D and F, suggests that the interaction between neurologic treatment and infection with different parasite strains has a substantial effect on the course of relapse; therefore, unadjusted relapse times from malariotherapy studies should be interpreted with caution.
10) Baratz blasts Wulsin: malariotherapy compared to Tuskegee experiments.
Malariotherapy is basically safe for HIV infection and it improves some immunological parameters of HIV positive patients (127) resulting in an increased CD4 count (128).
vivax has reportedly conferred partial resistance to induced infection during malariotherapy (2).
Other risk factors such as needle-sharing, malariotherapy, or organ transplants were discarded.