malaria parasite


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.
Related to malaria parasite: Plasmodium falciparum

malaria parasite

the PROTOZOAN Plasmodium that causes malaria in man. It is transmitted by the Anopheles mosquito which takes in Plasmodium GAMETOCYTES when feeding on man. The gametocytes develop into male and female gametes in the mosquito stomach, and after fertilization the ZYGOTE bores through the stomach wall, encysts, and gives rise to thousands of sporozoites which then migrate to the salivary glands. The sporozoites are transferred to man at a subsequent blood meal during which anticoagulants are injected with the saliva to prevent blood clotting.

Sporozoites invade the human liver and give rise to merozoites that invade red blood corpuscles. Further production of merozoites occurs in the red blood corpuscle and their release into the blood stream gives rise to bouts of fever (‘malaria’). Gametocytes arise from merozoites which invade further red blood corpuscles, grow within them, and are withdrawn by the mosquito during feeding, to complete the life cycle.

References in periodicals archive ?
Another promising class of antimalarial compounds triggered the same changes in red blood cells infected with the malaria parasite, researchers reported.
The children were followed for all of their medical care at a study clinic and screened each month for the malaria parasite.
The modified bacteria also have an alternative way of attacking the malaria parasite by binding to a protein in the mosquito's blood called plasminogen.
This reduced iron in the liver, preventing other malaria parasites from reproducing.
The vaccine, researchers said, would work by triggering an immune response in people so that they produce antibodies which target a protein the malaria parasite needs in order to reproduce within a mosquito.
Background & objectives: During a malaria epidemiological study in Arunachal Pradesh, Plasmodium malariae like human malaria parasites were seen in blood smears from fever cases.
However, researchers at Liverpool are looking at DNA sequencing of the malaria parasite.
Detection in patient samples of malaria parasite antigens such as histidine rich protein II (HRP-II) or plasmodium lactate dehydrogenase (pLDH) can be performed by rapid, point-of-care tests based on immunochromatographic methods.
The company's mission is to develop and commercialize a malaria sporozoite vaccine against Plasmodium falciparum, the parasite responsible for more than 95 percent of malaria-associated severe illness and death world-wide, and the malaria parasite for which there is the most significant drug resistance.
Mosquitoes carrying the malaria parasite, now restricted to the tropical north, could spread southward toward Pretoria, Cape Town, and Johannesburg.
This was highlighted by the deployment of the 26th Marine Expeditionary Unit to Liberia last year where there were casualty rates of 28 to 44 percent for troops with as little as 10 days of exposure to the malaria parasite," she added.
Theories put forward, such as that pregnant women are generally immuno-suppressed or that the placenta is a particularly nutritious niche for the malaria parasite, do not explain why increased susceptibility lessens with each subsequent pregnancy after the first.