Both malathion and malaoxon
are rapidly metabolized and their toxicity reduced with this enzyme system.
Other studies describe the possibility of malaoxon
to induce DNA breaks where the tumor suppressor genes are located so this metabolite of Malathion could be, considered as a potential carcinogen and mutagen, .
If this threshold was further decreased to 60%, an additional 3 chemicals would be selected, leaving only malaoxon
(56% similarity with mevinphos) unidentified from our analysis.
From the assay evaluation, the final purified ChE procedure displayed the highest sensitivity of detecting the anticholinesterase namely mercury, copper, malaoxon
and carbofuran compared to the impure ChE and the results were further discussed in detail to the potential application of ChE from P.
La toxicidad del malathion se debe a sus metabolitos, el malaoxon
e isomalathion, que son 40 veces mas toxicos que el malathion.
The toxic effects of malathion are related to its CYP-mediated oxidative desulfuration to bioactive malaoxon
leading to accretion of acetylcholine in neuroeffector junctions.
Malathion and malaoxon
PESTANAL analytical standards were purchased from Sigma-Aldrich (St Louis, MO).
However, malathion and its metabolite, malaoxon
, gave negative results for genotoxicity tests on S.
Results show that cytotoxicity of transformation products such as malaoxon
and paraoxon are increased compared to the parent pesticides.
The decrease of the sperm count at 15 and 30 days at dose of 600 mg malathion for kg of soil possibly indicates that the insecticide has been degraded to its active metabolites malaoxon
and isomalathion, which could also alter spermatogenesis (ATSDR, 2000).
Instead, it breaks down into malaoxon
and isomalathion; chemicals considerably more toxic than the original malathion itself.
A chemical survey of the Ruys' home revealed malathion and its toxic metabolite, malaoxon
, in 28 of the 40 samples taken from my clients' home.