malakoplakia


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mal·a·co·pla·ki·a

, malakoplakia (mal'ă-kō-plā'kē-ă, mal'a-kō-plā'kē-a),
Rare lesion in the mucosa of the urinary bladder and other organs, more frequent in women, characterized by numerous mottled yellow and gray soft plaques and nodules that consist of numerous macrophages and calcospherites (Michaelis-Guttmann bodies) that may form around intracellular bacteria, usually Escherichia coli.
[malaco- + G. plax, plate, plaque]

malakoplakia

A rare (less than 500 cases in the world literature) granulomatous lesion characterised by soft, yellow, elevated and friable 3–4 cm mucosal plaques of the genitourinary tract (bladder, renal pelvis, ureter, uterus, broad ligament, endometrium, testes, epididymis, prostate), with female:male ratio of 2.3:1 and, rarely, retroperitoneum, colon, stomach, appendix, lymph nodes, lungs, bone, skin. It is more common in immunosuppressed transplant recipients, a complication of recurrent infection, and attributed to defective phagocytosis. It may be associated with colorectal carcinoma.

Management
Long-term antibiotics, ascorbic acid, cholinergics; if recalcitrant, excision.

malakoplakia

malakos, Greek, soft plaque A lesion characterized by soft, yellow, elevated and friable 3-4 cm mucosal plaques of the GU tract–bladder, renal pelvis, ureter, uterus, broad ligament, endometrium, testes, epididymis, prostate and rarely, retroperitoneum, colon, stomach, appendix, lymph nodes, lungs, bone, skin; more common in immunosuppressed transplant recipients Treatment Long-term antibiotics, ascorbic acid, cholinergics; if recalcitrant, excision
References in periodicals archive ?
Keeping in view the findings of microscopic examination and results of special stains, a diagnosis of malakoplakia was made.
These are Tuberculous granulomas, Lepromatous granulomas, Foreign Body granulomas, Necrobiotic granulomas, Suppurative granulomas, Sarcoidal granulomas and Xanthgranulomas/ malakoplakia.
sup][4] To date, there are only very few case reports concerning antibiotics plus corticosteroids for treatment of renal malakoplakia.
We recognize the rarity of the case, with less than 1000 patients diagnosed with malakoplakia per year in the U.
DISCUSSION: Malakoplakia is a rare, chronic, granulomatous inflammatory disease, which was first described by Michaelis and Gutmann in 1902.
Pulmonary malakoplakia is an uncommon manifestation of Rhodococcus equi infection seen almost exclusively in HIV-infected patients.
The most widely accepted theory regarding the pathogenesis of calcification postulate that calcification are due to calcium deposition in areas of cellular degeneration associated with either an infection process, such as malakoplakia or with ischemic changes.
Malakoplakia is thought to be an inflammatory mass-forming process, composed of sheets of granular pink histiocytes (von Hansemann cells), which contain distinctive Michaelis-Gutmann bodies.
52) In rare situations, nonneoplastic processes, such as xanthogranulomatous pyelonephritis or malakoplakia, may present as a tumoral mass clinically, grossly, or microscopically.
Two benign closely related entities are malakoplakia and megalocytic interstitial nephritis.
Different types of renal cell neoplasms may closely simulate other non-renal cell neoplasms, such as angiomyolipoma, sarcoma, lymphoma, urothelial carcinoma, xanthogranulomatous pyelonephritis, malakoplakia, or metastatic carcinoma.