major breakpoint region

major breakpoint region

A 150-bp region of DNA on chromosome 18q21, located in the 3’ untranslated region of bcl-2 exon III. 50–70% of t(14:18) translocations, which are seen in most follicular lymphomas, are linked to the major breakpoint region and are identified by PCR.
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At the molecular level, breakpoints on chromosome 14 occur within the joining region genes (JH) of the 101 Most breakpoints on chromosome 18 are clustered within a 150-base pair (bp) segment at the 3' untranslated end of exon 3 of bc1-2, designated as the major breakpoint region (MBR) (7).
Twelve cell lines were examined for the t(14;18) chromosome rearrangement, using a probe that detects the bcl-2 major breakpoint region (Fig.
Detection of rearrangements of the BCL2 major breakpoint region in follicular lymphomas.

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