macular dystrophy


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Related to macular dystrophy: macular corneal dystrophy

macular dystrophy

any of a variety of eye disorders that damage the central part of the retina. Several of the disorders are related to gene mutations that affect older adults, including Sorsby's fundus dystrophy, caused by an excessive growth of blood vessels through the basal membrane, which thickens and bleeds. See also macular degeneration.

mac·u·lar ret·i·nal dys·tro·phy

(mak'yū-lahr ret'i-năl dis'trŏ-fē)
A group of disorders predominantly involving the posterior portion of the ocular fundus, due to degeneration in the sensory layer of the retina, retinal pigment epithelium, Bruch membrane, choroid, or a combination of these tissues.
See: Stargardt disease, Best disease
Synonym(s): macular dystrophy.

macular dystrophy

Any inherited, progressive degeneration of the macula lutea retinae marked by progressive central visual loss beginning in childhood or adolescence. Representative forms of macular dystrophy include Best disease and Stargardt disease. See: macula lutea retinae
See also: dystrophy
References in periodicals archive ?
Morphologic photoreceptor abnormality in occult macular dystrophy on spectral-domain optical coherence tomography.
Eventually she was diagnosed with macular dystrophy, which it appeared she'd had since birth.
DJ Laura Jones questioned whether she would be able to pursue her dream career in music when was diagnosed with Stargardt macular dystrophy at the age of 25.
Occult macular dystrophy is a hereditary macular dystrophy that presents with bilateral progressive vision loss while fundus appearance, fluorescein angiography and full-field electroretinogram are normal.
Don Mulryan, originally from Liverpool, has macular dystrophy, a degenerative eye condition that affects central vision.
In the two phase 112 studies, hESCs were differentiated into retinal pigment epithelium cells and transplanted into nine patients with Stargardt's macular dystrophy and nine patients with dry atrophic age-related macular degeneration, the leading causes of juvenile and adult blindness in the developed world, respectively.
The current World Champion in the T12 100m and 200m sprints suffers from a deteriorating eye condition known as Stargardt macular dystrophy, giving her only slight peripheral vision in her left eye.
and Europe for treatment of Stargardt's macular dystrophy (SMD) and dry age-related macular degeneration (dry AMD) with hESC-derived RPE cells.
The climber was diagnosed last year with Stargardt's macular dystrophy.
The biotechnology company, which is developing medical treatments based on human embryonic stem cells, said Tuesday it wants to modify its studies of a cellular treatment in patients with dry age-related macular degeneration and Stargardt's macular dystrophy.
These cell lines include one disease free pluripotent cell line and 24 others widi individual mutations that give rise to several severe diseases such as cancer (breast cancer, Wilm's tumor and Von Hippel-Lindau syndrome), Huntington's disease, muscular dystrophy (including CMT, FSHD and Myotonic) and cystic fibrosis as well as some rarer genetic diseases such as Trisomy 5, macular dystrophy, incontinentia pigmenti, juvenile retinoschisis, alpha thalassemia and autosomal dominant torsion dystonia.
Medicine company Advanced Cell Technology Inc (OTCBB:ACTC) said on Monday that it has selected Scotland's NHS Lothian as the site for its Phase I/II human clinical trial for Stargardt's Macular Dystrophy (SMD).

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