Among the 11 cases of macular amyloidosis, 8 had predominant upper limb involvement (left sided in 6) and posterior trunk alone affected in 3 cases of macular amyloidosis.
All the 7 clinically suggestive biphasic amyloidosis and 6 macular amyloidosis turned out to be lichen amyloidosis, and one lichen amyloidosis was histologically macular amyloidosis.
Other associated disorders are calciphylaxis, xerosis, xanthelasma, lipodystrophy, macular amyloidosis
Macular amyloidosis and lichen amyloidosis are named as biphasic amyloidosis when they are concurrently seen in a patient.
The term biphasic amyloidosis is used when macular amyloidosis and lichen amyloidosis coexist.
A RET mutation in exon 13 was confirmed in the latter; thus, it is unclear whether this patient had an unusual presentation of MEN2B or an overlap of MEN2A/2B, as the patient also had macular amyloidosis.
Multiple cutaneous neuromas and macular amyloidosis associated with medullary thyroid carcinoma.
with localized amyloidosis of upper air passages.
Patients who responded well to the drug included those with underlying diagnoses of liver cirrhosis, chronic renal failure, diabetes mellitus, cutaneous lymphoma, xerosis cutis, bullous pemphigoid, psoriasis, macular amyloidosis
, and prurigo nodularis (J.
On histopathological examination of 85 cases, 11 were classical Lichen planus and 09 were its morphological variants (Figure 2); 5 cases of Psoriasis, 5 cases of Prurigo nodularis, 4 cases of Morphea (Figure 3), 4 cases of Lichen simplex chronicus, 3 cases of Lichen striatus, 3 cases of Verruca plana, 3 cases of Becker nevus, 2 cases of Pemphigus foliaceus, 2 cases of Linear epidermal nevus (Figure 4), 2 cases of Macular amyloidosis
, 2 cases of Lentigo simplex, 2 cases of LSEA and one case each of other lesions as shown in Table 1.
There are many conditions which need to be considered before making a diagnosis of acquired macular hyperpigmentation like erythema dyschromicum perstans, lichen planus pigmentosus, macular amyloidosis
, tar and frictional melanosis, post-inflammatory hyperpigmentation, Berloque dermatitis, Riehl's melanosis and drugs and chemicals.
INTRODUCTION: Macular amyloidosis
(MA) is a common variant of primary localized cutaneous amyloidosis with a characteristic female preponderance [1-7] and the age of onset ranging between 21 and 50 years.