macrophagic myofascitis

macrophagic myofascitis

an inflammatory myopathy detected in patients with diffuse arthromyalgias and severe fatigue; characterized by muscle infiltration by granular periodic acid-Schiff reagent-positive macrophages and lymphocytes. The inclusions detected in the macrophages have been identified as aluminum hydroxide, an immunostimulatory compound used as a vaccine adjuvant.
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However, it has come under scrutiny due to concerns about aluminum related macrophagic myofascitis (43) and the potential for cumulative aluminum toxicity which has been associated with amyotrophic lateral sclerosis, Alzeimer's disease and dialysis-associated dementia (44).