macrophage migration inhibitory factor


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macrophage migration inhibitory factor

A 25-kD proinflammatory lymphokine, produced by T cells in response to antigenic stimulus, which inhibits macrophage migration.

Gene
MMIF is encoded by MIF on chromosome 22q11.23.

Activities
Cell-mediated immunity, inflammation and regulation of macrophage function in host defence by suppressing the anti-inflammatory effects of glucocorticoids.
 
Mechanism
Increases intracellular cAMP, polymerises microtubules, stops macrophage progression.
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References in periodicals archive ?
The report reviews Macrophage Migration Inhibitory Factor (Glycosylation-Inhibiting Factor or L-Dopachrome Isomerase or MIF or EC 5.
Macrophage migration inhibitory factor is a therapeutic target in treatment of non-insulin-dependent diabetes mellitus.
2]), Extracellular signal-regulated protein kinase (Erk), Inducible nitric oxide synthase (iNOS), Inhibitory factor kinase1/2/3 (IKK1/2/3), Lipopolysaccharide (LPS), Macrophage migration inhibitory factor (MIF), Mitogen activated protein kinase (MAPK), Nuclear factor-kappa B (NF-[kappa]B), Nitric oxide (NO), Phosphatidylinositol 3-kinase (PI3K), Protein kinase Akt (Akt), T-helper 1 lymphocytes (Th1), Toll-like receptor 4(TLR4), Transcription factor E2F (E2F), Transcription factor Sp1 (SP1)
Macrophage migration inhibitory factor is associated with positive cultures in patients with sepsis after cardiac surgery.
Pregnant women seeking treatment for major depression have markedly higher levels of macrophage migration inhibitory factor (MIF) than do nondepressed pregnant women of similar age.
AVANIR's small molecule research targets macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine that is thought to play a critical role in the pathology of disorders such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
Avanir's small molecules target macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine that plays a critical role in disorders such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
MN-166 is a first-in-class, orally bioavailable, small molecule phosphodiesterase (PDE) -4 and 10 inhibitor and a macrophage migration inhibitory factor (MIF) inhibitor that suppresses pro-inflammatory cytokines and promotes neurotrophic factors, concluded the company.
Blair continued, "In the area of collaborations, the first quarter was highlighted by our funded research collaboration with Baxter Healthcare Corporation, in which Baxter will utilize Dyax's proprietary phage display technology to discover antibodies that block macrophage migration inhibitory factor (MIF), a cytokine involved in immune, infectious and malignant disorders.
It will allow the discovery and development of potential oral first-in-class compounds that inhibit Macrophage Migration Inhibitory Factor, a major regulatory cytokine that has been linked genetically to the pathogenesis of several autoimmune and inflammatory diseases.
The AVANIR compounds target macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine that plays a critical role in inflammatory disorders such as rheumatoid arthritis, inflammatory bowel disease and psoriasis.
NASDAQ: DYAX) announced today a research collaboration with Baxter Healthcare Corporation (NYSE: BAX) to utilize Dyax's proprietary phage display technology to discover antibodies that block macrophage migration inhibitory factor (MIF), a clinical target to which Baxter has an exclusive license from Cytokine PharmaSciences, Inc.

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