macrophage migration inhibitory factor

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macrophage migration inhibitory factor

A 25-kD proinflammatory lymphokine, produced by T cells in response to antigenic stimulus, which inhibits macrophage migration.

MMIF is encoded by MIF on chromosome 22q11.23.

Cell-mediated immunity, inflammation and regulation of macrophage function in host defence by suppressing the anti-inflammatory effects of glucocorticoids.
Increases intracellular cAMP, polymerises microtubules, stops macrophage progression.
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Macrophage migration inhibitory factor levels correlate with fatal outcome in sepsis.
AVANIR's small molecule research targets macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine that is thought to play a critical role in the pathology of disorders such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
The AVANIR compounds target macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine that plays a critical role in inflammatory disorders such as rheumatoid arthritis, inflammatory bowel disease and psoriasis.
NASDAQ: DYAX) announced today a research collaboration with Baxter Healthcare Corporation (NYSE: BAX) to utilize Dyax's proprietary phage display technology to discover antibodies that block macrophage migration inhibitory factor (MIF), a clinical target to which Baxter has an exclusive license from Cytokine PharmaSciences, Inc.
In 2001, AVANIR added to its pre-clinical drug pipeline by acquiring a macrophage migration inhibitory factor (MIF) platform technology and is researching small molecule leads in the treatment of inflammation.
to develop and commercialize antibody therapeutics against macrophage migration inhibitory factor (MIF) for the treatment of inflammatory and autoimmune diseases.

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