macrolides


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Related to macrolides: clindamycin, Fluoroquinolones

mac·ro·lides

(mak'rō-līdz),
A class of antibiotics discovered in streptomycetes, characterized by molecules made up of large-ring lactones; for example, erythromycin; many inhibit protein biosynthesis.

macrolides

class of antibiotic with similar activity to penicillin, e.g. erythromycin, clarithromycin

mac·ro·lides

(mak'rō-līdz)
Class of antibiotics discovered in streptomycetes, e.g., erythromycin; many inhibit protein biosynthesis.

macrolides

(mak´rōlīdz),
n a class of antibiotics discovered in
Streptomyces, characterized by molecules made up of large-ring lactones. An example is erythromycin.
References in periodicals archive ?
Solithromycin is the First member of the Macrolide Class Since Azithromycin with the Potential for Both Intravenous and Oral Administration
sonnei UCN59, did not display any mutation in the critical bases of resistance to macrolides.
An advanced macrolide or respiratory fluoroquinolone is preferred for legionnaires' disease in hospitalized patients.
As macrolide and penicillin resistance grows and has the potential to cause more clinical failures, there is a need for new antibiotics with unique mechanisms of action that can overcome this emerging resistance.
MIC 2-4 mg/L) to only 14- and 15-member ring macrolides (M phenotype) because of mef gene-mediated active drug efflux mechanism.
A recent case-control study comparing penicillin-susceptible to penicillin-nonsusceptible isolates from patients with pneumococcal bacteremia identified prior exposure to [beta]-lactams, sulfonamides, and macrolides as risk factors; fluoroquinolone exposure was not a risk factor.
Testing for 23S rRNA mutations conferring macrolide resistance was performed on original specimens by real-time PCR melt curve analysis (6) and confirmed by DNA sequencing at the Lurie Children's Hospital (Chicago).
His laboratory has also investigated the anti-inflammatory activity of and inhibition of mucin production by azithromycin, a first-generation macrolide antibiotic.
While this study introduces an exciting concept in the field of COPD, I think that the concerns will prevent macrolides from being used widely in all patients with the condition.
GlaxoSmithKline & Biotica Technology Enter Collaboration to Discover & Develop Novel Erythromycin Macrolides
In Europe, studies have reported resistance to macrolides in more than 10% of strains tested from patients with S.
Notwithstanding the possible involvement of the well-documented, secondary anti-inflammatory properties of macrolides, the precise mechanisms which underpin the therapeutic efficacy of the beta-lactam/ macrolide combination remain to be established.