Solithromycin is the First member of the Macrolide
Class Since Azithromycin with the Potential for Both Intravenous and Oral Administration
sonnei UCN59, did not display any mutation in the critical bases of resistance to macrolides
An advanced macrolide
or respiratory fluoroquinolone is preferred for legionnaires' disease in hospitalized patients.
and penicillin resistance grows and has the potential to cause more clinical failures, there is a need for new antibiotics with unique mechanisms of action that can overcome this emerging resistance.
MIC 2-4 mg/L) to only 14- and 15-member ring macrolides
(M phenotype) because of mef gene-mediated active drug efflux mechanism.
A recent case-control study comparing penicillin-susceptible to penicillin-nonsusceptible isolates from patients with pneumococcal bacteremia identified prior exposure to [beta]-lactams, sulfonamides, and macrolides
as risk factors; fluoroquinolone exposure was not a risk factor.
Testing for 23S rRNA mutations conferring macrolide
resistance was performed on original specimens by real-time PCR melt curve analysis (6) and confirmed by DNA sequencing at the Lurie Children's Hospital (Chicago).
His laboratory has also investigated the anti-inflammatory activity of and inhibition of mucin production by azithromycin, a first-generation macrolide
While this study introduces an exciting concept in the field of COPD, I think that the concerns will prevent macrolides
from being used widely in all patients with the condition.
GlaxoSmithKline & Biotica Technology Enter Collaboration to Discover & Develop Novel Erythromycin Macrolides
In Europe, studies have reported resistance to macrolides
in more than 10% of strains tested from patients with S.
Notwithstanding the possible involvement of the well-documented, secondary anti-inflammatory properties of macrolides
, the precise mechanisms which underpin the therapeutic efficacy of the beta-lactam/ macrolide
combination remain to be established.