macroglobulin /mac·ro·glob·u·lin/ (mak″ro-glob´ūl-in) a globulin of unusually high molecular weight, in the range of 1,000,000.
macroglobulin
macroglobulin
α2-macroglobulin a plasma protein that inhibits a wide variety of proteolytic enzymes, including trypsin, plasmin, thrombin, kallikrein, and chymotrypsin, by entrapping and reducing the accessibility of their functional sites to large molecules.
mac·ro·glob·u·lin (m k r -gl b y -l n)n. A plasma globulin of high molecular weight. |
macroglobulin
[-glob′yəlin]
a globular serum protein with a molecular mass above 400 kilodaltons, such as the proteinase inhibitor alpha2-macroglobulin. See also immunoglobulin M.
macroglobulin
immunoglobulin M, an antibody protein (globulin) of molecular weight in the range of 1,000,000.
α2-macroglobulin
a glycoprotein that inhibits proteolytic enzymes. Increased levels are seen in diabetes mellitus and diseases of the liver and kidney.
macroglobulin
Any large serum protein, usually ≥ 400 kD–eg, IgM–900 kD, α2-macroglobulin–820 kD; macroglobulins are detected by sharp peaks on a simple zone electrophoresis, usually in the γ-region
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