macroglobulin


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macroglobulin

 [mak″ro-glob´u-lin]
a protein (globulin) of high molecular weight, in the range of 1,000,000; observed in the blood in a number of diseases.
α2-macroglobulin a plasma protein that inhibits a wide variety of proteolytic enzymes, including trypsin, plasmin, thrombin, kallikrein, and chymotrypsin, by entrapping and reducing the accessibility of their functional sites to large molecules. Written also alpha2-macroglobulin.

macroglobulin

/mac·ro·glob·u·lin/ (mak″ro-glob´ūl-in) a globulin of unusually high molecular weight, in the range of 1,000,000.
α2-macroglobulin  a plasma protein that inhibits a wide variety of proteolytic enzymes, including trypsin, plasmin, thrombin, kallikrein, and chymotrypsin, by entrapping and reducing the accessibility of their functional sites to large molecules.

macroglobulin

(măk′rō-glŏb′yə-lĭn)
n.
A plasma globulin of high molecular weight.

macroglobulin

[-glob′yəlin]
a globular serum protein with a molecular mass above 400 kilodaltons, such as the proteinase inhibitor alpha2-macroglobulin. See also immunoglobulin M.

macroglobulin

Any large serum protein, usually ≥ 400 kD—e.g., IgM (900 kD), α2-macroglobulin (820 kD). Macroglobulins are detected by sharp peaks on a simple zone electrophoresis, usually in the gamma region; because of the differing charges on the radicals, the electrophoretic mobility (pI) on the agar may shift and monoclonal spikes may occur in the beta or, less commonly, in the alpha region.

macroglobulin

Any large serum protein, usually ≥ 400 kD–eg, IgM–900 kD, α2-macroglobulin–820 kD; macroglobulins are detected by sharp peaks on a simple zone electrophoresis, usually in the γ-region

macroglobulin

See IgM.

macroglobulin

immunoglobulin M, an antibody protein (globulin) of molecular weight in the range of 1,000,000.

α2-macroglobulin
a glycoprotein that inhibits proteolytic enzymes. Increased levels are seen in diabetes mellitus and diseases of the liver and kidney.
References in periodicals archive ?
The senior investigator in whose lab I worked, Henry Metzger, was involved in defining the structure of macroglobulin (immunoglobulin M or IgM), using plasma from patients with Waldenstrom's macroglobulinemia.
Because this Waldenstrom macroglobulin was one of the first human monoclonal antibodies described and because of its clinical relevance, I was interested in pursuing it.
Alpha-2 macroglobulin attaches to the same cell surface protein as APP and APOE, the products of two other genes involved in Alzheimer's disease.
It's unclear how the identified mutation, a small deletion, affects alpha2 macroglobulin.
In addition, alfimeprase's thrombolytic activity appears to be localized to the site of delivery because it is rapidly inactivated by alpha-2 macroglobulin, a naturally occurring protein in the blood, as it moves away from the site of delivery and into the general blood circulation.
Alfimeprase's thrombolytic activity is localized to the site of delivery because it is rapidly inactivated by alpha-2 macroglobulin, a naturally occurring protein in the blood, as it moves away from the site of delivery and into the general blood circulation.
In addition, its lytic activity is localized to the site of delivery due to its rapid inhibition by alpha-2 macroglobulin, a naturally occurring protein in the blood, as soon as it moves away from the clot and into the general circulation.
Currently the most reliable serologic assessment of liver fibrosis uses a panel of 5 markers: [alpha]2 macroglobulin (a2M), haptoglobin, apolipoprotein [alpha]1 , y-glutamyl transpeptidase, and bilirubin (4).
1] Nonstandard abbreviations: HCV, hepatitis C virus; HCC, hepatocellular carcinoma; ECM, extracellular matrix; TGF-[beta]1, transforming growth factor [beta]1; HSC, hepatic stellate cell; HGF, hepatocyte growth factor; 2D, 2 dimensional; MS, mass spectroscopy; MS/MS, tandem MS; ITIH4, inter-[alpha]-trypsin inhibitor heavy chain H4; Apo L1, apolipoprotein L1; CD5L, CD5 antigen-like protein; [beta]2GPI, [beta]2 glycoprotein I; a2M, [alpha]2 macroglobulin.
FT is a noninvasive blood test that combines the quantitative results of 5 serum biochemical markers (alpha2 macroglobulin, haptoglobin, gamma glutamyl transpeptidase, total bilirubin, and apolipoprotein A1) with the patient's age and gender in a patented artificial intelligence algorithm (U.
Alpha-2 macroglobulin levels returned to baseline within 14 days of receiving drug.
In addition, preliminary testing suggests that alfimeprase's lytic activity is localized to the site of delivery because within seconds of moving away from the clot and into the general circulation, it is inhibited by alpha-2 macroglobulin, a naturally occurring protein in our blood.