macrofollicular

macrofollicular

/mac·ro·fol·lic·u·lar/ (-fah-lik´u-lar) pertaining to or characterized by large follicles.
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The most common differential diagnoses of encapsulated thyroid lesions are macrofollicular adenoma, adenomatoid nodule, follicular adenoma, follicular variant of papillary carcinoma and an encapsulated follicular carcinoma.
The differential diagnosis for the group included hyperplastic nodule, adenomatous follicular nodule, and macrofollicular adenoma.
Diffuse sclerosing and macrofollicular variants constituted 2% each.
It is most commonly encapsulated and may be microfollicular, normofollicular, or macrofollicular.
One case of hyalinising trabecular adenoma and another case of macrofollicular adenoma were reported.
Morphologically, these carcinomas have thick fibrous capsule and are composed of microfollicular and macrofollicular structures with light pink or dense red colloid-like secretions (Figure 3, D).
24,25] Macrofollicular architecture in a background of moderate abundant colloid is indicative of benign pathology, whereas, microfollicles and three dimensional clusters are a feature of follicular carcinomas as well as some adenomas.
B, Microfollicular (round), macrofollicular, glandular architectures; inset, cytology of the neoplastic cells: only focal/rare nuclear grooves, small cells, round and angulated nuclei, hyperchromasia, clumped chromatin, indistinct nucleoli, and little cytoplasm (hematoxylin-eosin, original magnifications X200 [a and b] and X400 [inset]).
6) Microscopically granulosa cell tumours are composed of granulosa cells, theca cells and fibroblasts and they exhibit various patterns like microfollicular, macrofollicular, trabecular and insular.
If the characteristic features of those formations are recognized, the pathologist should carefully reevaluate the normofollicular or macrofollicular nodule into which these foci are located.
Atypical cells, rule out a follicular neoplasm, had cells that were arranged in a mixed macrofollicular and microfollicular pattern, with minimal to no cytologic atypia.
It is important to survey the overall amount of colloid because macrofollicular groups, by nature, tend to shed mostly colloid, leaving any microfollicular groups as relatively conspicuous components of some aspirates.