macroenzyme

macroenzyme

(1) Obsolete for aspartate aminotransferase (AST).
(2) A normal enzyme or isoenzyme complexed to an immunoglobulin resulting in persistent false elevation, which may trigger an aggressive and/or invasive workup to identify a nonexistent condition.
 
Examples
Macro-amylase, macro-AST, macro-CK, macro-LD; most common in those > age 60; identified by serum electrophoresis.
References in periodicals archive ?
Macroenzyme as a cause of unexplained elevation of aspartate aminotransferase.
Although the clinical importance of macroenzymes is limited, the presence of a macroenzyme can be misleading in the interpretation of routine laboratory results (12), which can lead to a false conclusion of disease and to further expensive and dangerous investigations, or it can mask active disease (13).
University of Virginia Case Conference: macroamylase, macro creatine kinase and other macroenzymes.
Macroenzymes (3-5) are enzymes of high molecular mass that are formed in serum by self-polymerization or by association with other proteins.
Macro-aspartate aminotransferasemia: the macroenzyme phenomenon as a diagnostic dilemma.
Aspartate aminotransferase macroenzyme complex in serum identified and characterized.
Our findings suggest the possibility that a modified molecule of cTnI (6) induced the immunocomplex formation, differently from most cases of macroenzymes described in the literature (7) in which a modified immunoglobulin molecule (IgG or IgA) was the responsible complexing factor that bound the normal protein.
His PhD thesis described and characterized the first case of "macro-amylasemia" and led to worldwide studies on macroenzymes.
He launched his own transformation while still in his twenties by identifying the first of a novel class of oversized proteins, the macroenzymes, which opened up a whole new field of study.
At the mitochondrial level, the synthesis and degradation of the macroenzymes of the electron transport system (ETS) is a function of the respiratory requirements of marine organisms (Owens & King 1975).
Just a few of the topics to be covered include HbA 1c, vitamin D, metabolic syndrome, sepsis, Alpha-1 antitrypsin deficiency, the CDC's lipid standardization program, macroenzymes, cystic fibrosis screening, lab disaster preparation, liquid chromatography, preeclampsia, closing the HIV window, islet autoantibody testing, hemoglobinopathies, value-based reimbursement, chronic kidney disease, assessing anlayte stability, LDTs, prostate specific antigen, biomarkers in Alzheimer's disease, and many more.
Macroamylase, macro creatine kinase, and other macroenzymes.