macrocytic


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Related to macrocytic: macrocytic anemia, megaloblastic, hyperchromic, Normochromic, Normocytic

macrocytic

/mac·ro·cyt·ic/ (-sit´ik) pertaining to or characterized by macrocytes.

macrocytic

[mak′rōsit′ik]
Etymology: Gk, makros + kytos + L, icus, form
(of a cell) larger than normal, such as the erythrocytes in macrocytic anemia.

macrocytic

adjective Referring to enlarged cells or red blood cells.

anemia

Hematology A condition characterized by ↓ RBCs or Hb in the blood, resulting in ↓ O2 in peripheral tissues Clinical Fatigability, pallor, palpitations, SOB; anemias are divided into various groups based on cause–eg, iron deficiency anemia, megaloblastic anemia–due to ↓ vitamin B12 or folic acid, or aplastic anemia–where RBC precursors in BM are 'wiped out'. See Anemia of chronic disease, Anemia of investigation, Anemia of prematurity, Aplastic anemia, Arctic anemia, Autoimmune hemolytic anemia, Cloverleaf anemia, Congenital dyserythropoietic anemia, Dilutional anemia, Dimorphic anemia, Drug-induced immune hemolytic anemia, Fanconi anemia, Hemolytic anemia, Idiopathic sideroblastic anemia, Immune anemia, Iron-deficiency anemia, Juvenile pernicious anemia, Macrocytic anemia, Megaloblastic anemia, Microcytic anemia, Myelophthisic anemia, Neutropenic colitis with aplastic anemia, Nonimmune hemolytic anemia, Pseudoanemia, Refractory anemia with excess blasts, Sickle cell anemia, Sideroblastic anemia, Sports anemia.
General groups of anemia
Morphology
Macrocytic
Megaloblastic anemia
  • Vitamin B12deficiency
  • Folic acid deficiency
Microcytic hypochromic
  • Iron-deficiency anemia
  • Hereditary defects
  • Sickle cell anemia
  • Thalassemia
  • Other hemoglobinopathies
Normocytic
  • Acute blood loss
  • Hemolysis
  • BM failure
  • Anemia of chronic disease
  • Renal failure
Etiology
Deficiency
  • Iron
  • Vitamin B12
  • Folic acid
  • Pyridoxine
Central–due to BM failure
  • Anemia of chronic disease
  • Anemia of senescence
  • Malignancy
    • BM replacement by tumor
    • Toxicity due to chemotherapy
    • Primary BM malignancy, eg leukemia
Peripheral
  • Hemorrhage
  • Hemolysis
.

Macrocytic

A descriptive term applied to a larger than normal red blood cell.

macrocytic

manifested by or pertaining to the presence of macrocytes.
References in periodicals archive ?
Blood transfusion should be avoided as patients with macrocytic anaemia generally tolerate extremely low haemoglobin levels very well.
Strong correlations exist between both microcytic and macrocytic anemia.
and her contributors introduce hematology and its basic laboratory practice, including standard precautions, working from hematopoiesis to the complete blood count, understanding red blood cell production and its function and relevant red cell morphology, hemoglobin function and principles of hemolysis, red cell disorders such as the microcytic and macrocytic anemias, normochromic anemias, biochemical and membrane disorders and genetic disorders, white cell disorders including leukemias, hemostasis and disorders of coagulation, and a complete set of laboratory procedures.
In the first case, a girl aged 15 months was hospitalized in August 2001 after her pediatrician diagnosed her with failure to thrive, developmental delay and severe macrocytic anemia.
Carbohydrate-deficient transferrin, gamma-glutamyltransferase, and macrocytic volume as biomarkers of alcohol problems in women.
It also helps prevent macrocytic anaemia, a disease in which blood cells grow larger than normal, and have a shorter lifespan.
If there is significant variation in size with microcytic, normocytic, and macrocytic cells present, the MCV may be normal because it is the average of cell size.
Pancytopenia, including macrocytic anemia, associated with leflunomide in a rheumatoid arthritis patient.
He had macrocytic anemia with normal folate and vitamin B12 levels.
The Sysmex XE-5000 analyser (Sysmex Corporation, Kobe, Japan) is now capable of estimating percentages of microcytic, macrocytic, hypochromic and hyperchromic red cells.
A disease state, such as a macrocytic anemia, could certainly confound this determination, for example, by increasing maternal cell size, or MCV, into the fetal range.