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macrocyte

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macrocyte /mac·ro·cyte/ (mak´ro-sīt) an abnormally large erythrocyte.
mac·ro·cyte (mkr-st)
n.
An abnormally large red blood cell, especially one associated with pernicious anemia.

macro·cytic (-stk) n.

macrocyte
[mak′rəsīt]
Etymology: Gk, makros + kytos, cell
an abnormally large mature erythrocyte usually exceeding 9 μm in diameter that is commonly seen in megaloblastic anemias, for example, vitamin B12 deficiency. Compare microcyte. See also macrocytic anemia.

macrocyte [mak´ro-sīt]
an abnormally large erythrocyte. adj., adj macrocyt´ic.

macrocyte,
n a red blood cell that is unusually large; usually seen in megaloblastic anemias (e.g., B12 deficiency).

macrocyte
an abnormally large erythrocyte.


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Laboratory data usually show severe and progressive hypochromic anemia, leukopenia with a predominance of lymphocytes and macrocytes, thrombocytopenia, hypoalbuminemia with polyclonal hypergamaglobulinemia and, at times, even an increase in liver function tests.
Diagnostic Features: Pancytopenia, oval macrocytes,and hypersegmented neutrophils; megaloblastic hyperplasia; achlorhydria; anti-intrinsic factor antibodies; absent position and vibration sensations; impaired vitamin B12 absorption corrected by intrinsic factor (abnormal Schilling test) =>Folate deficiency +Mechnisms: Delayed DNA replication +Diagnostic Features: Pancytopenia, oval mcrocytes, and hypersegmented neutrophils; megaloblastic hyperplasia.
 
 
 
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