macroautophagy


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macroautophagy

(mak'rō-aw-tŏf'a-jē),
A function of highly conserved genes that control the isolation of cytoplasmic constituents into autophagosomes and diverts them from the lysosomal pathway.
References in periodicals archive ?
With macroautophagy, for example, too little can cause degeneration while too much can result in cell death (Klionsky).
In alternative macroautophagy, autophagic membranes are generated from Golgi-derived thick membranes, and thus can easily fuse with the thick membranes of lysosomes.
Chronic elevated ROS levels and the oxidative stress, pathophysiological parainflammation, and long stay hypoxia decrease the ability of RPE cells to remove damaged or nonfunctional proteins via the lysosomal clearance system, including macroautophagy [214].
Macroautophagy is thought to be the major type of autophagy and it has been studied most extensively compared to microautophagy and chaperone-mediated autophagy [46].
Involvement of macroautophagy in multiple system atrophy and protein aggregate formation in oligodendrocytes.
Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells.
Our hypothesis is based on an assumption that macroautophagy and selective mitophagy are the mechanisms maintaining cellular homeostasis of ASC derived from EMS horses during their differentiation into chondrogenic cells, thus keeping their functionality and maintaining regenerative potential.
It was found that autophagy was induced in mutants unable to grow in nutrient-poor media and the activation of macroautophagy as an anti-aging mechanism is essential for yeast cells in the absence of food (Nishida et al.
2008) Wild type a-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells.
Three forms of autophagy have been identified: chaperone-mediated autophagy, microautophagy, and macroautophagy.
Autophagy has been classified into three types: macroautophagy (hereafter referred to as autophagy), microautophagy, and chaperone-mediated autophagy (CMA) [18].
In accordance with that, EGCG has been shown to promote macroautophagy and lysosome recycling of accumulated intracellular materials [52, 53].