MELAS

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MELAS

Acronym for mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes. One of the mitochondrial disorders, this condition is usually hereditary, with a mutation at the mitochondrial genome at locus 3243.

MELAS

Mitochondrial Encephalomyopathy with Lactic Acidosis & Stroke-like episodes. A childhood condition associated with intermittent vomiting, proximal limb weakness and recurrent cerebral insults, resulting in hemiparesis, hemianopia or cortical blindness.
 
MELAS is due to an adenine-to-guanine substitution in a highly conserved portion of gene for tRNALeu(UUR), impairing the termination of mitochondrial transcription.

MELAS

Mitochondrial Encephalomyopathy with Lactic Acidosis & Stroke-like episodes Neurology A childhood condition, associated with intermittent vomiting, proximal limb weakness, and recurrent cerebral insults resulting in hemiparesis, hemianopia or cortical blindness. Cf MERRF.

MELAS

(mel'as)
Acronym for a constellation of findings that includes mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes. One of the mitochondrial disorders, this condition is usually hereditary, with a mutation at the mitochondrial genome at locus 3243.