Elastin is made from its precursor molecule tropoelastin, which forms elastic fibers after key steps involving the enzyme lysyl
oxidase-like 1 (LOXL1) and glycoprotein fibulin-5 (FBLN5).
The company's development pipeline is centred on its expertise in amine oxidase chemistry and includes Semicarbazide-Sensitive Amine Oxidase Inhibitors (SSAO) for Non-alcoholic Steatohepatitis (NASH) and inflammatory diseases including Chronic Obstructive Pulmonary Disease (COPD), and Lysyl
Oxidase Inhibitors (LOX) targeting fibrotic diseases including pulmonary fibrosis and some cancers.
Lox-Age uses the power of chicory (Cichorium intybus) to restore expression of lysyl
oxidase (LOX), a key protein that becomes scarce with age.
oxidase and MMP-2 expression in dehydroepiandrosterone-induced polycystic ovary in rats.
GA reacts with '- amino group of lysyl
residues in proteins which induces the formation of interchain crosslinks and stabilizes tissues against chemical and enzymatic degradation depending upon the extent of cross-linking (11).
Among the minerals required for skeletal formation, colloidal system maintenance, acid--base balance, and enzyme activities, Cu has been considered increasingly important in crustacean nutrition because of its functions in hematopoiesis and in numerous Cu-dependent enzymes including lysyl
oxidase, cytochrome c oxidase, ferroxidase, tyrosinase, and superoxide dismutase (SOD) (Lall 2002).
Indeed, collagen cross-linking by lysyl
oxidase (LOX) recently appeared as a key determinant of late-stage tumors and metastases (6).
If experts can successfully block the action of lysyl
oxidase-like 2 (LOXL2), then treatments could be developed to stop the spread of breast cancer.
oxidase is essential for hypoxia-induced metastasis.
The enzyme called lysyl
oxidase (LOX) has been found to stiffen collagen, a major component of the supportive tissue in the breast.
Some of the members of this class of cuproenzymes include Cu/Zn SOD (antioxidant defense), cytochrome C oxidase (mitochondrial respiration), CP (iron metabolism), tyrosinase (pigmentation), lysyl
oxidase (collagen maturation in connective tissue), Hephaestin (intestinal iron efflux), dopamine [[beta]-hydroxylase (catecholamine synthesis), Peptidylglycine [alpha] -amidating monooxygenase (peptide-hormone processing), amine oxidase (removal of hormones), ascorbate oxidase and catalase oxidase (oxidation of primary alcohols to aldehydes) (44).
Downregulation of lysyl
oxidase and upregulation of cellular thiols in rat fetal lung fibroblasts treated with cigarette smoke condensate.