lysosome


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Related to lysosome: primary lysosome

lysosome

 [li´so-sōm]
one of the minute bodies occurring in many types of cells, containing various hydrolytic enzymes and normally involved in the process of localized intracellular digestion. adj., adj lysoso´mal.

ly·so·some

(lī'sō-sōm),
A cytoplasmic membrane-bound vesicle measuring 5-8 nm (primary lysosome) and containing a wide variety of glycoprotein hydrolytic enzymes active at an acid pH; serves to digest exogenous material, such as bacteria, as well as effete organelles of the cells.
[lyso- + G. soma, body]

lysosome

/ly·so·some/ (li´so-sōm) one of the minute bodies occurring in many types of cells, containing various hydrolytic enzymes and normally involved in the process of localized intracellular digestion.lysoso´mal
secondary lysosome  one that has fused with a phagosome (or pinosome), bringing hydrolases in contact with the ingested material and resulting in digestion of the material.

lysosome

(lī′sə-sōm′)
n.
A membrane-bound organelle in the cytoplasm of most cells containing various hydrolytic enzymes that function in intracellular digestion.

ly′so·so′mal adj.

lysosome

[lī′səsōm]
Etymology: Gk, lysein + soma, body
a cytoplasmic, membrane-bound particle that contains hydrolytic enzymes that function in intracellular digestive processes. The organelles are found in most cells but are particularly prominent in leukocytes and the cells of the liver and kidney. If the hydrolytic enzymes are released into the cytoplasm, they cause self-digestion of the cell. Thus lysosomes may play an important role in certain self-destructive diseases characterized by the wasting of tissue, such as muscular dystrophy.

ly·so·some

(lī'sō-sōm)
A cytoplasmic membrane-bound vesicle measuring 5-8 nm (primary lysosome) and containing a wide variety of glycoprotein hydrolytic enzymes active at an acid pH; serves to digest exogenous material, such as bacteria, as well as effete organelles of the cells.
[lyso- + G. soma, body]

lysosome

One of the types of ORGANELLE found in cell cytoplasm. Lysosomes contain various hydrolytic enzymes capable of digesting large molecules (macromolecules), the products of which can then leave the lysosomes. Injury to lysosomes may release enzymes that can damage the cell.

lysosome

a cytoplasmic organelle of EUKARYOTE cells that contains hydrolytic enzymes and is thought to be produced by the GOLGI APPARATUS. The sac-like structure is surrounded by a single-layered membrane which is impermeable and resistant to the enzymes inside. Lysosomes can act as the digestive system of the cell. When the sac ruptures the enzymes are released into a food vacuole produced by PHAGOCYTOSIS, thus enabling the breakdown of ingested materials.

Lysosome

Membrane-enclosed compartment in cells, containing many hydrolytic enzymes; where large molecules and cellular components are broken down.
Mentioned in: Mucopolysaccharidoses

ly·so·some

(lī'sō-sōm)
A cytoplasmic membrane-bound vesicle (primary lysosome) and containing a wide variety of glycoprotein hydrolytic enzymes active at an acid pH; serves to digest exogenous material, such as bacteria.
[lyso- + G. soma, body]

lysosome

a small intracellular organelle occurring in the cytoplasm of most cells, containing various hydrolytic enzymes and normally involved in the process of localized intracellular digestion. Lysosomes are particularly prominent in certain cells such as granulocytes, in which they are the granules, and activated macrophages. They play a major role in intracellular killing of microorganisms, destruction of foreign or damaged tissues, and in embryogenesis.
References in periodicals archive ?
At the end of the emersion period heart rate was assessed for each adult and a second 1 mL hemolymph sample taken for lysosome and metal analysis.
50) They also showed that one of the enzymes that is defective in inherited cases of Alzheimer's disease is required for effective lysosome function.
Ultrastructural examination of neurons revealed complex arrangements of whorled or stacked membranes admixed with finely granular material and homogenous lipid droplets, with costorage of diverse materials within the same lysosome.
Bafilomycin is an ATPase inhibitor causing a loss of H+ from the lysosome and ultimately inhibiting autophagosome maturation.
He helped discover lysosomes in 1955, visualizing the organelle that Christian de Duve had characterized only cytochemically.
Gangliosidoses are one of the compounds that are broken down in these lysosomes, so they're like the plastic conveyor belt.
Observed increases in the numbers of lysosomes suggest further cellular degradation.
Now we know that arsenite destabilizes lysosomes, a part of a cell that contains certain enzymes, which, when released, often kill APL cells.
Given that during synthesis of the C/Fe particulates, the material is subjected to extreme acidification procedures, the acidification reached in a lysosome would not be sufficient to decompose the particle.
This shift to alkalinity reduces the activities of lysosomal proteinases and results in less-than-optimal protein hydrolysis in the lysosome.
Exogenously administered lysosomal enzyme re is taken up in cells through cell-surface mannose-6-phosphare receptors, and transported to the lysosome in order to degrade the toxic build-up of accumulated metabolite.
Glycogen, a complex sugar, is known to accumulate in both the cytoplasm and lysosome of adult-onset Pompe patients; however, the currently approved enzyme-replacement product is limited to the lysosome for therapeutic activity.