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lysergic acid diethylamide, a hallucinogen derived from lysergic acid, a constituent of ergot alkaloids. It has consciousness-expanding effects and is capable of producing a state of mind in which there are hallucinations (false sense perceptions). Called also lysergide. The perceptual changes brought about by LSD in normal persons are extremely variable and depend on factors such as age, personality, education, physical make-up, and state of health. The danger of the drug lies in the fact that it loosens control over impulsive behavior and may lead to a full-blown psychosis or less serious mental disorder in persons with latent mental illness. See also drug abuse.
ly·ser·gic ac·id di·eth·yl·am·ide (LSD),
peripherally, a serotonin antagonist; 1-2 mcg or less per kg induces hallucinatory states; its use may precipitate psychoses; it was formerly occasionally used in the treatment of long-term alcoholism and psychotic disorders.
lysergide/ly·ser·gide/ (li-ser´jīd) lysergic acid diethylamide.
a psychotomimetic, semisynthetic derivative of ergot that acts at multiple sites in the central nervous system from the cortex to the spinal cord. In susceptible individuals, as little as 20 to 25 mg of the potent drug may cause pupillary dilation, increased blood pressure, hyperreflexia, tremor, muscle weakness, piloerection, and increased body temperature. Larger doses also produce dizziness, drowsiness, paresthesia, euphoria or dysphoria, and synesthesias. Colors may be heard, sounds visualized, and time is felt to pass slowly. Psychological dependence may develop, and use of lysergide is associated with significant hazards such as panic, serious depression, paranoid behavior, and prolonged psychotic episodes. Also called (slang) acid, LSD (an abbreviation of the original German name, Lyserg-Säure-Diäthylamid, (lysergic acid diethylamide). See also hallucinogen.
lysergic acid diethylamide.