lyophilization


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lyophilization

 [li-of″ĭ-lĭ-za´shun]
the creation of a stable preparation of a biologic substance by rapid freezing and dehydration of the frozen product under high vacuum. See also freeze-drying.

ly·oph·i·li·za·tion

(lī-of'i-li-zā'shŭn),
1. The process of isolating a solid substance from solution by freezing the solution and evaporating the ice under vacuum.
2. The process of imparting lyophilic properties to a substance.
Synonym(s): freeze-drying

lyophilization

/ly·oph·i·li·za·tion/ (li-of″ĭ-lĭ-za´shun) the creation of a stable preparation of a biological substance by rapid freezing and dehydration of the frozen product under high vacuum.

lyophilization

Freeze drying A method for preserving foods or biologicals, where a substance–eg, coagulation factor VIII, is 'snap-frozen' in liquid nitrogen–-70ºC and placed in a high vacuum to remove the water vapor as it sublimes; once the water is removed, the substance is brought to room temperature and stored. Cf Quick-freeze technique.

ly·oph·i·li·za·tion

(lī-of'i-lī-zā'shŭn)
The process of isolating a solid substance from solution by freezing the solution and evaporating the ice under vacuum.
Synonym(s): freeze-drying.

lyophilization

see FREEZE-DRYING.

lyophilization

the creation of a stable preparation of a biological substance by rapid freezing and dehydration of the frozen product under high vacuum. Called also freeze-drying.
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References in periodicals archive ?
Q: With the growing demand for lyophilization, is it correct to say that manufacturing processes need to be optimized and modernized?
Lyophilization Services of New England, Inc ("LSNE") is a privately held company with three GMP facilities located in New Hampshire.
To get a comprehensive overview of the global lyophilization equipment market
Lyophilization: Efficacy of lyophilization was evaluated by direct lyophilization of the fungal mat and lyophilization of the fungal spawn.
As the pressure rises, so does the boiling point of the solvents, leading to poor lyophilization results, and possibly to complete lyophilization failure.
The results indicated a better amount and quality for the genomic DNA extracted using the modified method with the previous tissue lyophilization and the addition of PVP before the maceration step.
The advantage of lyophilization is hospitals and tissue banks don't need huge freezers to store it and tissue can basically be shelf-ready.
Lyophilization is used for a limited number of applications, such as those that involve proteins, enzymes, microorganisms and blood plasma, all of which are heat sensitive.
The successful inspection was conducted primarily with regard to two additional products manufactured on behalf of clients in the DRAXIS Pharma sterile lyophilization (freeze-drying) production facility.
Lyophilization is the process of removing water from a product by sublimation.
Lyophilization is commonly utilized to preserve starter cultures and to increase storage times for subsequent use in food fermentations.