Tezepelumab is a novel anti-thymic stromal lymphopoietin
(TSLP) monoclonal antibody being developed by MedImmune, AstraZeneca's global biologics research and development arm, in collaboration with Amgen.
Expression and cellular provenance of thymic stromal lymphopoietin
and chemokines in patients with severe asthma and chronic obstructive pulmonary disease.
Triclosan induces thymic stromal lymphopoietin
in skin promoting Th2 allergic responses.
In light of recent developments surrounding tumor immunotherapy, the researchers decided to combine 5-FU with calcipotriol (calcipotriene, approved for psoriasis), which induces thymic stromal lymphopoietin
(TSLP), "an epithelium-derived cytokine and a master regulator of allergic inflammation in the skin," according to the authors.
Disruption of the skin barrier activates the adaptive immune alarm system; several cytokines have been identified in this process, including interleukin (IL)-33, thymic stromal lymphopoietin
(TSLP), IL-25, toll-like receptors, and other inflammasome-activating signals.
He believes pollen, dust mites and similar allergens trigger the protein thymic stromal lymphopoietin
(TSLP), which is produced by cells called keratinocytes in the skin's outermost layer.
Gingival crevicular fluid levels of interferon-[gamma], but not interleukin-4 or -33 or thymic stromal lymphopoietin
, are increased in inflamed sites in patients with periodontal disease," Journal of Periodontal Research, vol.
f/+f] mice exhibited increased levels of thymic stromal lymphopoietin
receptor (TSLPR) in DSS colitis.
Dibutyl phthalate-induced thymic stromal lymphopoietin
is required for Th2 contact hypersensitivity responses.
Human thymic stromal lymphopoietin
enhances expression of CD80 in human CD14+ monocytes/ macrophages.
It was known that the epithelial cells which line the airways in the lungs produce a protein called thymic stromal lymphopoietin
(TSLP) that causes inflammation.
Further, recent studies have demonstrated that thymic stromal lymphopoietin
(TSLP) may be expressed in keratinocytes, affected by skin barrier defects.