NEW YORK, July 1, 2015 /PRNewswire/ -- Thymic stromal lymphopoietin
(TSLP) is an IL-7-like cytokine that play various roles in a broad spectrum of biological procedures.
MicroRNA-375 regulation of thymic stromal lymphopoietin
by diesel exhaust particles and ambient particulate matter in human bronchial epithelial cells.
It was known that the epithelial cells which line the airways in the lungs produce a protein called thymic stromal lymphopoietin
(TSLP) that causes inflammation.
Thymic stromal lymphopoietin
(TSLP) is an important immunologic factor involved in the pathogenesis of AD (Iyengar et al.
One of these genes encodes the protein thymic stromal lymphopoietin
(TSLP), which plays a critical role in sensing environmental agents and triggering immune response.
Harper also discussed AMG 157, a human monoclonal antibody that inhibits the action of Thymic Stromal Lymphopoietin
(TSLP), as an example of Amgen's innovative approach in inflammation.
Their research shows that NH resistance to steroids is induced by the protein thymic stromal lymphopoietin
(TSLP), present in the airways of severe asthma patients.
Interestingly, another phthalate, di-n-butyl phthalate, up-regulated skin hypersensitivity reactions via thymic stromal lymphopoietin
, a cytokine known to activate the maturation of dendritic cells and recently associated with eczema, in mice (Larson et al.
May 20, 2014 /PRNewswire/ -- Amgen (NASDAQ:AMGN) today announced that The New England Journal of Medicine(NEJM) published positive results from a Phase 1 study adding to the growing body of evidence that inhibiting thymic stromal lymphopoietin
(TSLP) could be beneficial in the treatment of asthma.
In earlier work, researchers from CHOP, along with collaborators at Cincinnati Children's Hospital, found that genetic mutations in the gene that encodes for thymic stromal lymphopoietin
(TSLP), a protein that is produced by epithelial cells that line the esophagus and directs the activities of various types of immune cells, are highly associated with EoE in children.
Karolina Palucka and colleagues have found that human breast cancer cells release the cytokine thymic stromal lymphopoietin
(TSLP) and that TSLP drives Th2 inflammation in human breast tumors.
The aggravation was consistent with eosinophilic inflammation, mast cell degranulation, and thymic stromal lymphopoietin
(TSLP) expression in the ear.