lymphomatoid granulomatosis

lymphomatoid granulomatosis

n.

A disease characterized by granulomatous proliferations of atypical white blood cells, plasma cells, and histiocytes that invade and destroy the small arteries of the lung, skin, kidneys, and nervous system; it usually affects adult men and may develop into lymphoma. Also called polymorphic reticulosis.

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lymphomatoid granulomatosis

[limfō′mətoid]

a condition of unknown cause in which lymphocytes and plasma cells infiltrate the blood vessels, producing an angiocentric lesion. It most often affects the lungs, causing chest pains, cough, and shortness of breath. See also Wegener's granulomatosis.

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lymphomatoid granulomatosis

a rare pulmonary neoplasm of dogs characterized by infiltration by atypical lymphoreticular cells.

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lymphomatoid granulomatosis

A lymphoproliferative disorder which presents in middle-aged subjects with well-circumscribed bilateral nodules seen on CXR; some cases occur in immunosuppressed renal transplant recipients and in Pts with Sjögren syndrome Clinical 80% have extrapulmonary involvement–eg, skin, CNS, kidneys, liver, spleen, adrenal glands, heart, GI tract, etc Prognosis 64% mortality; median survival of 14 months, death is due to pulmonary destruction accompanied by sepsis; severe T-cell impairment may explain the tendency for malignant degeneration. Cf Lymphoid interstitial pneumonia.