Fatal haemoptysis in a case of lymphomatoid
granulomatosis treated with rituximab.
granulomatosis (LYG) is an angiocentric and angiodestructive process that commonly affects the lung as bilateral nodular infiltrates, mimicking Wegener granulomatosis both clinically and radiographically.
Lack of c-kit (CD117) expression in CD30+ lymphomas and lymphomatoid
Kontos AP, Kerr HA, Malick F, Fivenson DP, Lim HW, Wong HK: 308-nm excimer laser for the treatment of lymphomatoid
papulosis and stage IA mycosis fungoides.
The time between the start of therapy and onset of skin conditions varied, but some events looked more likely to be drug related, including the eruptions, cutaneous vasculitis, a case of systemic lupus erythematosus, dermatomyositis, and a lymphomatoid
papulosis-like eruption, the authors continued.
Incorrect diagnoses occur mainly because many diseases are mistakenly diagnosed as spider bites, including many conditions much more prevalent and serious, such as staphylococcal or streptococcal infection, herpes simplex and zoster, erythema multiforme, diabetic ulcer, fungal infection, pyoderma gangrenosum, lymphomatoid
papulosis, syphilis, and Lyme disease.
16,17) It affects patients older than 50 years who do not have a known immunodeficiency and do not meet criteria for other EBV-associated processes or lymphomas (such as infectious mononucleosis, lymphomatoid
granulomatosis, and plasmablastic lymphoma).
The differential diagnoses include lymphomatoid
granulomatosis, primary CNS lymphoma, CD5+ diffuse large B-cell lymphoma, reactive lymphoid hyperplasia, CNS vasculitis, HPC-associated disorders other than IVLBCL, the acute leukemias, and lymphomas with an intravascular component.
The study includes patients with relapsed or refractory CD30-expressing cutaneous T-cell disease, including cutaneous ALCL, transformed mycosis fungoides and lymphomatoid
granulomatosis is recognized as an angiocentric and angiodestructive disease arising in a variety of extranodal sites.
The study was recently amended to include two other related CD30-positive indications: transformed mycosis fungoides and lymphomatoid
gastropathy: a distinct clinicopathologic entity of self-limited pseudomalignant NK-cell proliferation.