papulosis expresses immunophenotypes associated with T cell lymphoma but not inflammation.
The primary cutaneous CD30+ lymphoproliferative disorders include Anaplastic large T cell lymphoma/null-cell primary cutaneous type ALCL, lymphomatoid
papulosis (LyP), and borderline cases of the EORTC classification with overlapping features of the other two conditions.
Fatal haemoptysis in a case of lymphomatoid
granulomatosis treated with rituximab.
These histologic changes were most consistent with lymphomatoid
Several other large B-cell lymphomas are occasionally or always positive for EBV, including PBL, primary effusion lymphoma, DLBCL associated with chronic inflammation, and lymphomatoid
Some of the pseudolymphomas that can fool the clinician include lymphomatoid
drug eruption, cutaneous leishmaniasis, lymphomatoid
lichenoid keratosis, and reactive lymphoid hyperplasia at the site of vaccination.
In addition, many types of cutaneous lymphoma can have similar histomorphologic features--for example, some tumoral lesions of mycosis fungoides (MF) with large cell transformation cannot be reliably distinguished from anaplastic large cell lymphoma or lymphomatoid
papulosis by hematoxylin-eosin sections or even IHC.
Kontos AP, Kerr HA, Malick F, Fivenson DP, Lim HW, Wong HK: 308-nm excimer laser for the treatment of lymphomatoid
papulosis and stage IA mycosis fungoides.
The time between the start of therapy and onset of skin conditions varied, but some events looked more likely to be drug related, including the eruptions, cutaneous vasculitis, a case of systemic lupus erythematosus, dermatomyositis, and a lymphomatoid
cells are a feature of lymphomatoid
papulosis, especially types A, C, D, and E; large cell transformation of mycosis fungoides and ALCL.
These include bronchial asthma, allergic broncho-pulmonary aspergillosis (ABPA), acute eosinophilic pneumonia, chronic eosinophilic pneumonia, idiopathic hypereosinophilic syndrome, Wegener's granulomatosis, lymphomatoid
granulomatosis, Churg-Strauss syndrome, some malignancies, and drug hypersensitivity reactions.
Incorrect diagnoses occur mainly because many diseases are mistakenly diagnosed as spider bites, including many conditions much more prevalent and serious, such as staphylococcal or streptococcal infection, herpes simplex and zoster, erythema multiforme, diabetic ulcer, fungal infection, pyoderma gangrenosum, lymphomatoid
papulosis, syphilis, and Lyme disease.