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lymphokine |
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lymphokine /lym·pho·kine/ (lim´fo-kīn) a general term for soluble protein mediators postulated to be released by sensitized lymphocytes on contact with antigen, and believed to play a role in macrophage activation, lymphocyte transformation, and cell-mediated immunity.
lymphokine [lim′fōkīn] Etymology: L, lympha + Gk, kinesis, motion one of the chemical factors produced and released by T lymphocytes that attract macrophages to the site of infection or inflammation and prepare them for attack. Kinds of lymphokines include chemotactic factor, cytokine, lymphotoxin, migration inhibiting factor, and mitogenic factor. lymphokine soluble protein mediators released by lymphocytes undergoing blastogenesis following contact with antigen. Lymphokines influence the behavior of the cells that produce them (autocrine) and of other cells in the vicinity (paracrine) and cells at a distance (endocrine), including macrophages, neutrophils, lymphocytes and other cells; a subset of cytokines many of which are also defined as interleukins. lymphokine-activated killer (LAK) cells cytotoxic T lymphocytes produced by incubation with interleukin 2. See also K cells. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Research shows that ozone depletion also may exacerbate the effect of climate change on infectious disease as well as cause immunosuppression by altering T-cells and lymphokine production. Peptide specificity and HLA restriction do not dictate lymphokine production by allergen-specific T-lymphocyte clones. Histopathologic and immunologic studies of acute HPS patients have shown antibodies, significant CD8 and CD4 T-lymphocyte activation, and lymphokine involvement, suggesting the hypothesis that HPS is an immunopathologic response to hantavirus infection (6,7,13,17,18). |
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