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lymphokine

   Also found in: Dictionary/thesaurus, Wikipedia, Hutchinson 0.03 sec.
lymphokine /lym·pho·kine/ (lim´fo-kin) a general term for soluble protein mediators postulated to be released by sensitized lymphocytes on contact with antigen, and believed to play a role in macrophage activation, lymphocyte transformation, and cell-mediated immunity.
lym·pho·kine (lmf-kn)
n.
Any of various soluble substances, released by sensitized lymphocytes on contact with specific antigens, that act by stimulating activity of monocytes and macrophages.
lymphokine
soluble protein mediators released by lymphocytes undergoing blastogenesis following contact with antigen. Lymphokines influence the behavior of the cells that produce them (autocrine) and of other cells in the vicinity (paracrine) and cells at a distance (endocrine), including macrophages, neutrophils, lymphocytes and other cells; a subset of cytokines many of which are also defined as interleukins.
lymphokine-activated killer (LAK) cells
cytotoxic T lymphocytes produced by incubation with interleukin 2. See also K cells.
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Research shows that ozone depletion also may exacerbate the effect of climate change on infectious disease as well as cause immunosuppression by altering T-cells and lymphokine production.
The lessons of extraordinary times by Osbourne, Diana / New Life Journal
Peptide specificity and HLA restriction do not dictate lymphokine production by allergen-specific T-lymphocyte clones.
A human dendritic cell-based method to identify CD[4.sup.+] T-cell ... by Harding, Fiona / Environmental Health Perspectives
Histopathologic and immunologic studies of acute HPS patients have shown antibodies, significant CD8 and CD4 T-lymphocyte activation, and lymphokine involvement, suggesting the hypothesis that HPS is an immunopathologic response to hantavirus infection (6,7,13,17,18).
Acute Sin Nombre hantavirus infection without pulmonary syndrome, ... by Ksiazek, thomas G. / Emerging Infectious Diseases
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