lymphokine


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lymphokine

 [lim´fo-kīn]
any of various soluble protein mediators released by sensitized lymphocytes on contact with antigen, and believed to play a role in macrophage activation, lymphocyte transformation, and cell-mediated immunity. It regulates immune responses through differentiation, amplification, and inhibition of cell functions. Lymphokines may also have a cytotoxic effector function. Used as biologic response modifiers in the treatment of cancer.

lym·pho·kine

(lim'fō-kīn),
Hormonelike peptide, released by activated lymphocytes, which mediates immune response; a cytokine obtained from lymphocytes.
[lymphocyte + G. kineō, to set in motion]

lymphokine

/lym·pho·kine/ (lim´fo-kīn) a general term for soluble protein mediators postulated to be released by sensitized lymphocytes on contact with antigen, and believed to play a role in macrophage activation, lymphocyte transformation, and cell-mediated immunity.

lymphokine

(lĭm′fə-kīn′)
n.
Any of various soluble substances, released by sensitized lymphocytes on contact with specific antigens, that act by stimulating activity of monocytes and macrophages.

lymphokine

[lim′fōkīn]
Etymology: L, lympha + Gk, kinesis, motion
one of the chemical factors produced and released by T lymphocytes that attract macrophages to the site of infection or inflammation and prepare them for attack. Kinds of lymphokines include chemotactic factor, cytokine, lymphotoxin, migration inhibiting factor, and mitogenic factor.

lymphokine

An older term for what is now designated interleukin-2 (IL2).

lym·pho·kine

(lim'fō-kīn)
Hormonelike peptide, released by activated lymphocytes, which mediates immune response; a cytokine obtained from lymphocytes.
[lymphocyte + G. kineō, to set in motion]

lymphokine

a soluble mediator released by lymphocytes on contact with specific antigens.

lymphokine

soluble protein mediators released by lymphocytes undergoing blastogenesis following contact with antigen. Lymphokines influence the behavior of the cells that produce them (autocrine) and of other cells in the vicinity (paracrine) and cells at a distance (endocrine), including macrophages, neutrophils, lymphocytes and other cells; a subset of cytokines many of which are also defined as interleukins.

lymphokine-activated killer (LAK) cells
cytotoxic T lymphocytes produced by incubation with interleukin 2. See also K cells.
References in periodicals archive ?
Helper T-cells produce powerful chemicals, called lymphokines, that mobilize other immune system substances and cells.
Interleukin 4: a prototypic immunoregulatory lymphokine.
Hargis of Texas A&M University's veterinary pathology department have collaborated on studies showing lymphokine injections could significantly reduce organ invasion by Salmonella enteritidis, a type of salmonella found primarily in eggs.
Antigen-activated T-cell multiplication has long been associated with the lymphokine IL-2's role in the immune response (Harrington et al.
A diffusible lymphokine produced by CD8+ T lymphocytes suppresses HIV replication.
After these cells are primed for combat against cancer by exposure to the lymphokine called interleukin 2, a stimulant of T-cell growth, they are put back into the patient.
If we are to avoid wasting precious resources on therapies looking for diseases to treat (as may be the case for interleukin-2, a lymphokine developed for treating kidney cancer), we need clearer guidelines of what constitutes an indication for therapy and how much society is willing to invest in underwriting treatments for rare disorders, or unproven remedies for treating common ones.
An example of a lymphokine that stimulates macrophages is interferon.
Yamamoto in 2007 published his work on GcMAF (globulin component protein-derived macrophage activating factor), a lymphokine that makes macrophages cytotoxic to tumors and blocks nagalase (alpha-N-acetylgalactosaminidase), which inhibits the production of GcMAF (without which the immune system literally goes to sleep).
7] Immunobiological therapy involving transfer of Lymphokine Activated Killer (LAK) cells has shown to increase the 5-year survival rate in patients.