lymphokine


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lymphokine

 [lim´fo-kīn]
any of various soluble protein mediators released by sensitized lymphocytes on contact with antigen, and believed to play a role in macrophage activation, lymphocyte transformation, and cell-mediated immunity. It regulates immune responses through differentiation, amplification, and inhibition of cell functions. Lymphokines may also have a cytotoxic effector function. Used as biologic response modifiers in the treatment of cancer.

lym·pho·kine

(lim'fō-kīn),
Hormonelike peptide, released by activated lymphocytes, which mediates immune response; a cytokine obtained from lymphocytes.
[lymphocyte + G. kineō, to set in motion]

lymphokine

/lym·pho·kine/ (lim´fo-kīn) a general term for soluble protein mediators postulated to be released by sensitized lymphocytes on contact with antigen, and believed to play a role in macrophage activation, lymphocyte transformation, and cell-mediated immunity.

lymphokine

(lĭm′fə-kīn′)
n.
Any of various soluble substances, released by sensitized lymphocytes on contact with specific antigens, that act by stimulating activity of monocytes and macrophages.

lymphokine

[lim′fōkīn]
Etymology: L, lympha + Gk, kinesis, motion
one of the chemical factors produced and released by T lymphocytes that attract macrophages to the site of infection or inflammation and prepare them for attack. Kinds of lymphokines include chemotactic factor, cytokine, lymphotoxin, migration inhibiting factor, and mitogenic factor.

lymphokine

An older term for what is now designated interleukin-2 (IL2).

lym·pho·kine

(lim'fō-kīn)
Hormonelike peptide, released by activated lymphocytes, which mediates immune response; a cytokine obtained from lymphocytes.
[lymphocyte + G. kineō, to set in motion]

lymphokine

a soluble mediator released by lymphocytes on contact with specific antigens.

lymphokine

soluble protein mediators released by lymphocytes undergoing blastogenesis following contact with antigen. Lymphokines influence the behavior of the cells that produce them (autocrine) and of other cells in the vicinity (paracrine) and cells at a distance (endocrine), including macrophages, neutrophils, lymphocytes and other cells; a subset of cytokines many of which are also defined as interleukins.

lymphokine-activated killer (LAK) cells
cytotoxic T lymphocytes produced by incubation with interleukin 2. See also K cells.
References in periodicals archive ?
In tests, Kogut and colleagues have shown that if day-old chicks are given lymphokines, heterophils are on hand within hours to provide the kind of protection that a bird's immune system could take a week to develop naturally.
Glucocorticoids also inhibit the production of lymphokines, resulting in a decreased immune response.
When we are feeling happy, these nerves start firing and release chemical substances called leucokines or lymphokines into the blood stream.
23,27] Tests of production and secretion by T lymphocytes of IL-2 and other lymphokines detect increases, decreases and no changes.
The lymphocytes then secrete powerful substances called lymphokines, which may speed up the progression of atherosclerosis, Villa speculates.
This 286-page report presents comprehensive marketing and technological assessment, as well as medical rationale and diagnostic prospects, for the major categories of both circulating and cellular tests, such as Biochemical Markers, Oncogenes, Growth Factors, Hormones, Colony Stimulating Factors, Lymphokines, Immunohistochemical Stains and others.
com/research/dxfg9g/2015_market) has announced the addition of the "2015 Market Segmentation Analysis of the German Cancer Diagnostics Industry: Oncogenes, Biochemical Markers, Lymphokines, GFs, CSFs, Hormones, Immunohistochemical Stains--Hospitals, Commercial Labs and Physician Offices" report to their offering.
it induces anti-inflammatory cytokines and lymphokines, reduces inflammatory ones, and promotes antibacterial and antiviral activity.
Certain ones, such as the enzymes that protect against free radicals and the lymphokines, produced in the immune system, are being studied extensively by gerontologists.
The stimulated macrophages secrete chemotactic factors such as lymphokines, which then attract T-helper (T4) lymphocytes.
This new invention has overcome these problems, and will allow radioactive phosphorus to be linked to a variety of disease-targeting proteins, such as antibodies, lymphokines, cytokines, growth factors, and other molecules, thus generating new categories of therapeutics," he remarked further.