A skin biopsy specimen showed perineural lymphohistiocytic
inflammation and nonnecrotizing granulomata (Figure, panel B).
67) Cell mediated rejection is characterized by a lymphohistiocytic
(T cell predominant) and eosinophilic infiltrate that starts in the dermal vasculature, proceeds to dermal or epidermal junction, causes dermal or epidermal separation, and finally results in irreversible epidermal necrosis.
The infiltrate was predominantly lymphohistiocytic
(E) and present in a background of increased dermal mucin (F).
Twelve showed sparse lymphohistiocytic
infiltrates in the upper dermis.
syndrome: Unrecognized cause of multiple organ failure.
One of these patients underwent a protocol-based regimen, according to hereditary lymphohistiocytic
hemophagocytosis group trial (HLH-2004).
We performed a liver biopsy that showed periportal fibrosis with presence of plasma cells, acidophilic bodies and balloon degeneration and a skin biopsy that revealed the presence of necrotic basal keratinocytes, focal oedema and perivascular lymphohistiocytic
Biopsies of both the right arm (triceps muscle) and right thigh (vastus lateralis muscle) were taken, and the MRI of the right arm revealed inflammatory myositis (focal mild perivascular and endomysial lymphohistiocytic
inflammation), (Figure 2).
Video-assisted thoracoscopic surgery (VATS) and wedge biopsy of the lung revealed lymph node pathology, epithelioid granulomata with Langhans giant cells and lymphohistiocytic
Histologically, cicatricial pemphigoid is characterized by the formation of subepithelial bullae that contain lymphohistiocytic
infiltrates and a small number of eosinophils.
Severe nonsuppurative meningitis (with > 20 layers of lymphohistiocytic
cells), perineuritis, and encephalomyelitis were found within the nervous system.
Histopathologic evaluation also included evaluation for an interstitial pattern of the lymphohistiocytic
infiltrate (consistent with "incomplete" granuloma annulare) or a palisading pattern with central necrobiosis (granuloma annulare, common variant), increased dermal mucin deposition (highlighted by colloidal iron stain), presence of multinucleated giant cells, elastophagocytosis, and eosinophils.