lymphocytic hypophysitis

lym·pho·cy·tic hy·po·phy·si·tis

an acute anterior pituitary lymphocytic reaction characterized clinically by signs and symptoms of anterior pituitary insufficiency; probably an autoimmune disorder because antipituitary antibodies are present in the serum.

lymphocytic hypophysitis

the massive infiltration of the pituitary gland by lymphocytes and plasma cells, with destruction of the normal parenchyma. The disorder is believed to have an autoimmune basis.

lymphocytic hypophysitis

A relatively rare autoimmune disease in which the pituitary gland is infiltrated and damaged by lymphocytes, esp. during pregnancy or the postpartum period. Imaging studies of the pituitary gland show massive enlargement.. Imaging studies of the pituitary gland show massive enlargement. Hormone deficiencies, or in some cases, hyperprolactinemia, can occur.
Synonym: autoimmune hypophysitis
See also: hypophysitis
References in periodicals archive ?
Combined granulomatous and lymphocytic hypophysitis presenting as pituitary incidentaloma in a middle-aged woman.
2) Lymphocytic hypophysitis is a rare autoimmune cause for Hypogonadotropic hypogonadism generally in peripartum women rarely in men.
Lymphocytic hypophysitis with diabetes insipidus in a young man.
Case report and bibliographic review about lymphocytic hypophysitis in childhood
Lymphocytic hypophysitis presenting with diabetes insipidusus: case report and literature review.
Infectious or inflammatory causes include meningitis, lymphocytic hypophysitis and granulomatous inflammations such as sarcoidosis, Wegener's granulomatosis.
His findings reveal eight are suffering from lymphocytic hypophysitis - which usually affects just one in 500million men.
Autoimmune hypophysitis ultimately can give the picture of empty sella on pituitary imaging and cannot be ruled out at present, although GH deficiency is considered to be less common in lymphocytic hypophysitis and pituitary stalk was not thickened in the present patient (12,14).
Distinct radiological and clinical appearance of lymphocytic hypophysitis.
Lymphocytic hypophysitis is an autoimmune process of both cellular and humoral type, as evidenced by predominance of CD8+ T cells (39) and the presence in serum of antibodies directed against pituitary hormones, most often prolactin (40-42) or adrenocorticotropic hormone.
Lymphocytic hypophysitis of pregnancy resulting in hypopituitarism: a distinct clinicopathologic entity.
Lymphocytic hypophysitis with central diabetes insipidus and consequent panhypopituitarism preceding a multifocal, intracranial germinoma in a prepubertal girl.

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