lymphocyte transformation


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lym·pho·cyte trans·for·ma·tion

the transformation into large, blastlike forms (immunoblasts) that occurs when lymphocytes are exposed to histoincompatible antigens (mixed lymphocyte culture) or mitogens.
See also: mixed lymphocyte culture test.

lymphocyte transformation

1 the morphological changes accompanying lymphocyte activation, in which small, resting lymphocytes are transformed into large, active lymphocytes (lymphoblasts).
2 an in vitro immunity test process in which a patient's lymphocytes are placed in a culture with an antigen. The rate of transformation, in terms of proliferation and enlargement of T memory cells, is measured by the uptake of radioactive thymidine by the lymphocytes, indicating protein synthesis.
References in periodicals archive ?
A novel lymphocyte transformation test (LTT-MELISA[R]) for Lyme borreliosis.
The lymphocyte transformation test for borrelia detects active Lyme borreliosis and verifies effective antibiotic treatment.
Increased tendency to spontaneous in-vitro lymphocyte transformation in clinically active multiple sclerosis.
The discrimination between nickel-sensitive and non-nickelsensitive subjects by an in vitro lymphocyte transformation test.
Due to the limitations of skin testing (Rietschel 1996), alternative methods are currently being tested for the detection of type IV hypersensitivities, including such methods as lymphocyte transformation tests (Pichler and Tilch 2004).
The lymphocyte transformation test is an in vitro assay that measures the proliferation of T cells following an antigen challenge (Warrington and Tse 1979).
The lymphocyte transformation test in the diagnosis of drug hypersensitivity.
Key words: Kampo medicine, liver injury, lymphocyte transformation test, side effect
A secondary objective was to examine the clinical reliability of the lymphocyte transformation test (LTT) for the diagnosis of Kampo-medicine-induced liver injury.
Results of lymphocyte transformation tests (LTTs) for Kampo medicines were also reviewed.
The results of a lymphocyte transformation test were reported as not significant.

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