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The formation of lymphatics (lymphatic vessels).
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M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis.
Kataru RR Jung K, Jang C, et al: Critical role of CD11b+ macrophages and VEGF in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution.
Changes in regulatory molecules for lymphangiogenesis in intestinal lymphangiectasia with enteric protein loss.
They are associated with lymphangiogenesis arising in the setting of chronic lymphedema.
It has been shown to inhibit angiogenesis and lymphangiogenesis in the vascularization of platinum sensitive tumor types.
Dry eye predisposes to corneal neovascularization and lymphangiogenesis after corneal injury in a murine model.
mTOR is a downstream signal in the vascular endothelial growth factor (VEGF) C/D pathway, and mTOR inhibitors such as sirolimus are capable of inhibiting lymphangiogenesis in vitro.
Angiopoietin1 and -2 exert antagonistic functions in tumor angiogenesis, yet both induce lymphangiogenesis.
Since VEGF-C was previously reported to be active in angiogenesis, lymphangiogenesis, endothelial cell growth, survival, and permeability of blood vessels, it appeared possible that MSCs express VEGF-C.
Basic scientists, surgeons, radiologists, and immunologists from around the world present important developments into the biology and clinical understanding of cancer metastasis, describe the relationship between tumor microenvironment and proliferation, and define the process of lymphangiogenesis and angiogenesis.
They are believed to be associated with lymphangiogenesis arising in the setting of chronic lymphoedema [25].