luteinizing hormone-releasing hormone agonist


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luteinizing hormone-releasing hormone agonist

LH-RH agonist Endocrinology Any substance that simulates LH-RH which, with time, result in a ↓ sex hormone secretion. See H-RH.
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When luteinizing hormone-releasing hormone agonists are first prescribed, there is a temporary flare of testosterone production that may last for 30 days before testicular testosterone production shuts down.
Median testosterone levels grouped by treatment arm (Time @ -6 months = baseline testosterone level and first luteinizing hormone-releasing hormone agonist (LHRH-A) injection; time @ 0 months = end of LHRH-A treatment).
The study, a double-blind, randomized controlled clinical trial conducted throughout North America and published in the clinical journal Urology(1) compared CASODEX with another agent, flutamide(2), each given in combination with a luteinizing hormone-releasing hormone agonist (LHRH-A) in 813 patients with advanced prostate cancer.

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