Oral dosages of another experimental HNO prodrug, CXL-1036, produced enhanced inotropy (systolic pump function), lusitropy
(diastolic relaxation) and vasodilation while decreasing cardiac energy demand in animal models.
Impact of restrictive physiology on intrinsic diastolic right ventricular function and lusitropy
in children and adolescents after repair of tetralogy of Fallot.
Traditionally, understanding of cardiovascular physiology starts with widely used but non-quantitative cardiocentric concepts such as inotropy and lusitropy
, the relaxation properties of the heart in diastole.
This action is similar to positive lusitropy
induced by ISO, which is known to result from stimulation of SR [Ca.
In athlete's heart, this is reflected in better inotropy, lusitropy
, and augmented cardiac pumping capacity (Katz and Lorell, 2000), which are clearly an advantage.
Internists, family physicians, and even cardiologists who aren't echocardiographers find baffling the terms we routinely use to describe diastolic dysfunction: impaired relaxation, restrictive filling, lusitropy
, and here's one that really messes people up--pseudonormalization.
Influence of altered inotropy and lusitropy
on ventricular pressure-volume loops.
CXL-1020, a Novel HNO Donor, Decreases Myocardial Loading and Enhances Load-Independent Lusitropy
and Inotropy via a Beta-AR/ACE Independent Mechanism.