Abstract: Pimobendan is a phosphodiesterase (PDE) inhibitor and calcium sensitizer with inotropic, lusitropic
, and rasodilator properties used in the treatment of congestive heart failure.
Effects of istaroxime on diastolic stiffness in acute heart failure syndromes: results from the Hemodynamic, Echocardiographic, and Neurohormonal Effects of Istaroxime, a Novel Intravenous Inotropic and Lusitropic
Agent: a Randomized Controlled Trial in Patients Hospitalized with Heart Failure (HORIZON-HF) trial.
A positive lusitropic
effect of NO has previously been reported in contracting papillary muscle strips, isolated ejecting guinea-pig heart and following intracoronary infusions in humans (22-24).
The two gases were found to interact together to form a thiol-sensitive compound (linked to the sulphur in H2S) which produces inotropic (muscular contraction) and lusitropic
(muscular relaxation) effects in the heart.
LVdp/dt, marker of myocardial contraction) and lusitropic
(-LVdp/dt, marker of myocardial relaxation) states of the heart.
Debio 0614 is a novel intravenous agent combining inotropic and lusitropic
Analysis of lusitropic
indices (A, E, or E/A) indicated that the E/A ratio was higher in BP as compared with that of strength/power athletes (p < 0.
In preclinical studies using models of hypertension and heart failure, Vasomera(TM)demonstrated prolonged and significant dose dependent reductions in mean arterial pressure as well as positive inotropic and lusitropic
effects without increasing myocardial oxygen consumption.
However, the lusitropic
response to b adrenergic agents was abnormal regardless of restrictive physiology.
Istaroxime is an innovative luso-inotropic agent which combines an inotropic (stimulation of myocardial contractility during systole) and lusitropic
(improvment of diastolic relaxation) effect through an original dual mode of action.
The nitric oxide-releasing and vasodilating properties of nebivolol in coronary microvessels may also underlie its beneficial effects in patients with ischemic and dilated cardiomyopathies, particularly those with diastolic dysfunction, given the direct lusitropic
properties of nitric oxide on the myocardium (47, 48).
hBNP has multiple biological activities (through natriuretic, diuretic, vasorelaxant, and lusitropic
properties) that contribute to its therapeutic use in treating heart failure.