lupus /lu·pus/ (loo´pus) any of a group of skin diseases in which the lesions are characteristically eroded.
chilblain lupus erythematosus a form due to cold-induced microvascular injury, aggravated by cold; the lesions initially resemble chilblains but eventually assume the form of discoid lupus erythematosus.
cutaneous lupus erythematosus one of the two main forms of lupus erythematosus, in which the skin may be either the only or the first organ or system involved. It may be chronic (discoid l. erythematosus), subacute (systemic l. erythematosus), or acute (characterized by an acute, edematous, erythematous eruption).
discoid lupus erythematosus (DLE) a chronic form of cutaneous lupus erythematosus marked by red macules covered with scanty adherent scales that fall off and leave scars; lesions typically form a butterfly pattern over the bridge of the nose and cheeks, but other areas may be involved.
drug-induced lupus a syndrome closely resembling systemic lupus erythematosus, precipitated by prolonged use of certain drugs, most commonly hydralazine, isoniazid, various anticonvulsants, and procainamide.
lupus erythemato´sus (LE) a group of chronic connective tissue diseases manifested in two main types: cutaneous l. erythematosus and systemic l. erythematosus.
lupus erythemato´sus profun´dus a form of cutaneous lupus erythematosus in which deep brawny indurations or subcutaneous nodules occur under normal or, less often, involved skin; the overlying skin may be erythematous, atrophic, and ulcerated and on healing may leave a depressed scar.
lupus erythemato´sus tu´midus a variant of discoid or systemic lupus erythematosus in which the lesions are raised reddish purple or brown plaques.
hypertrophic lupus erythematosus a form of discoid lupus erythematosus characterized by verrucous hyperkeratotic lesions.
lupus hypertro´phicus
1. a variant of lupus vulgaris in which the lesions consist of a warty vegetative growth, often crusted or slightly exudative, usually occurring on moist areas near body orifices.
lupus milia´ris dissemina´tus fa´ciei a form marked by multiple, discrete, superficial nodules on the face, particularly on the eyelids, upper lip, chin, and nares.
neonatal lupus a rash resembling discoid lupus erythematosus, sometimes with systemic abnormalities such as heart block or hepatosplenomegaly, in infants of mothers with systemic lupus erythematosus; it is usually benign and self-limited.
lupus per´nio
1. a cutaneous manifestation of sarcoidosis consisting of violaceous smooth shiny plaques on the ears, forehead, nose, and digits, frequently associated with bone cysts.
systemic lupus erythematosus (SLE) a chronic generalized connective tissue disorder, ranging from mild to fulminating, marked by skin eruptions, arthralgia, arthritis, leukopenia, anemia, visceral lesions, neurologic manifestations, lymphadenopathy, fever, and other constitutional symptoms. Typically, there are many abnormal immunologic phenomena, including hypergammaglobulinemia and hypocomplementemia, deposition of antigen-antibody complexes, and the presence of antinuclear antibodies and LE cells.
lupus vulga´ris the most common and severe form of tuberculosis of the skin, most often affecting the face, with formation of red-brown patches of nodules in the dermis that progressively spread peripherally with central atrophy, causing ulceration and scarring and destruction of cartilage in involved sites.
lupus erythematosus pro·fun·dus (pr -f n d s)n. A chronic cutaneous form of lupus erythematosus giving rise to deep-seated, firm, rubbery nodules that sometimes become ulcerated, usually on the face. |
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