lupus erythematosus

lupus /lu·pus/ (loo´pus) any of a group of skin diseases in which the lesions are characteristically eroded.

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chilblain lupus erythematosus  a form due to cold-induced microvascular injury, aggravated by cold; the lesions initially resemble chilblains but eventually assume the form of discoid lupus erythematosus.

cutaneous lupus erythematosus  one of the two main forms of lupus erythematosus, in which the skin may be either the only or the first organ or system involved. It may be chronic (discoid l. erythematosus), subacute (systemic l. erythematosus), or acute (characterized by an acute, edematous, erythematous eruption).

discoid lupus erythematosus  (DLE) a chronic form of cutaneous lupus erythematosus marked by red macules covered with scanty adherent scales that fall off and leave scars; lesions typically form a butterfly pattern over the bridge of the nose and cheeks, but other areas may be involved.

drug-induced lupus  a syndrome closely resembling systemic lupus erythematosus, precipitated by prolonged use of certain drugs, most commonly hydralazine, isoniazid, various anticonvulsants, and procainamide.

lupus erythemato´sus  (LE) a group of chronic connective tissue diseases manifested in two main types: cutaneous l. erythematosus and systemic l. erythematosus.

lupus erythemato´sus profun´dus  a form of cutaneous lupus erythematosus in which deep brawny indurations or subcutaneous nodules occur under normal or, less often, involved skin; the overlying skin may be erythematous, atrophic, and ulcerated and on healing may leave a depressed scar.

lupus erythemato´sus tu´midus  a variant of discoid or systemic lupus erythematosus in which the lesions are raised reddish purple or brown plaques.

hypertrophic lupus erythematosus  a form of discoid lupus erythematosus characterized by verrucous hyperkeratotic lesions.

lupus hypertro´phicus 

1. a variant of lupus vulgaris in which the lesions consist of a warty vegetative growth, often crusted or slightly exudative, usually occurring on moist areas near body orifices.

2. hypertrophic l. erythematosus.

lupus milia´ris dissemina´tus fa´ciei  a form marked by multiple, discrete, superficial nodules on the face, particularly on the eyelids, upper lip, chin, and nares.

neonatal lupus  a rash resembling discoid lupus erythematosus, sometimes with systemic abnormalities such as heart block or hepatosplenomegaly, in infants of mothers with systemic lupus erythematosus; it is usually benign and self-limited.

lupus per´nio 

1. a cutaneous manifestation of sarcoidosis consisting of violaceous smooth shiny plaques on the ears, forehead, nose, and digits, frequently associated with bone cysts.

2. chilblain l. erythematosus.

systemic lupus erythematosus  (SLE) a chronic generalized connective tissue disorder, ranging from mild to fulminating, marked by skin eruptions, arthralgia, arthritis, leukopenia, anemia, visceral lesions, neurologic manifestations, lymphadenopathy, fever, and other constitutional symptoms. Typically, there are many abnormal immunologic phenomena, including hypergammaglobulinemia and hypocomplementemia, deposition of antigen-antibody complexes, and the presence of antinuclear antibodies and LE cells.

lupus vulga´ris  the most common and severe form of tuberculosis of the skin, most often affecting the face, with formation of red-brown patches of nodules in the dermis that progressively spread peripherally with central atrophy, causing ulceration and scarring and destruction of cartilage in involved sites.

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lupus er·y·the·ma·to·sus (r-thm-tss, -thm-)

n.

1. Abbr. LE A chronic disease of unknown origin characterized by red, scaly lesions or patches on the face and upper portion of the trunk.

2. Systemic lupus erythematosus.

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Lupus erythematosus

A chronic inflammatory disease in which inappropriate immune system reactions cause abnormalities in the blood vessels and connective tissue.

Mentioned in: Abortion, Therapeutic, Alopecia, Diuretics, Dysfunctional Uterine Bleeding

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lupus erythematosus.

See systemic lupus erythematosus.

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lupus (loo´pus),

n a disease of the skin and mucous membrane.

Lupus.

lupus erythematosus (systemic lupus erythematosus, disseminated lupus erythematosus),

n a chronic inflammatory disease of unknown etiology affecting skin, joints, kidneys, nervous system, serous membranes, and often other organs of the body. The classical facial “butterfly rash” facilitates diagnosis, although the rash need not be present. Other skin areas, particularly those exposed to the sun, may be involved by a scaly lesion that is referred to as
discoid lupus erythematosus.

lupus erythematosus, discoid,

n a form in which only cutaneous lesions are present. These commonly appear on the face as atrophic plaques with erythema, hyperheratosis, follicular plugging, and telangiectasia.

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lupus erythematosus

Disseminated lupus erythematosus, lupus, systemic lupus erythematosus Rheumatology An idiopathic multisystem collagen vascular (connective tissue) disorder Epidemiology Affects ±40/105–North America, Europe, blacks/Hispanics > whites, ♀:♂ ratio = 3:1; 80% onset during childbearing yrs Clinical Vasculitis, serositis, synovitis, cerebral, renal, skin involvement Cause of death Sepsis 40%, CVS 20%, CNS 10%, 10% nephritis with possible renal failure, others 20%. See ANA-negative systemic lupus erythematosus, Anticardiolipin antibody, Antinuclear antibody, Butterfly rash.

Systemic lupus erythematosus–1982 revised criteria

1. Malar rash Fixed erythema, in particular over the malar eminences

2. Discoid rash Raised erythematous patches with adherent hyperkeratotic scaling; atrophic scarring in some old lesions

3. Photosensitivity Unusual skin rashes in response to sunlight

4. Oral ulcers Oral or nasopharyngeal ulcers

5. Arthritis Nonerosive arthritis of 2+ joints, accompanied by tenderness, swelling, or effusions

6. Serositis  

 a. Pleuritis OR

 b. Pericarditis

7. Renal disease  

 a. Persistent proteinuria > 0.5 g/day OR

 b. Cellular casts

8. Neurologic disorder  

 a. Seizures without substance use or medical disease OR

 b. Psychosis in absence of substance use or medical disease

9. Hematologic disorder  

 a. Hemolytic anemia OR

 b. Leukopenia OR

 c. Lymphocytopenia

 d. Thrombocytopenia

10. Immunologic disorder  

 a. Positive LE cell prep–this test was abandoned in the mid-1990s

 b. Anti-DNA antibody

 c. Anti-Sm antibody

 d. False positive serological test for syphilis

11 Antinuclear antibody Abnormal titers of ANA in absence of drugs known to be associated with drug-induced lupus erythematosus

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Patient discussion about lupus erythematosus.

Q. I need to do an interview with someone with knowledge on lupus for a research paper any takers? a couple of questions should do it. it doesn't have to be extensive.

A. I HAVE SLE AND A FUW MORE THANS THAT ARE KNOW TO BE KNOW TO COME FROM HAVEING SLE LUPUS I AM NOT 100% OF ALL THAT COMES WITH SLE BUT I AM WILLING TO TELL U ALL I KNOW THANK YOU

Q. Is a rash a symptom of lupus? My Sister has lupus for several years now. I recently developed a rash on my face. Is this a symptom of lupus? Could I have also been infected with this disease?

A. A rash could be a symptom of cutaneous lupus. The symptoms of cutaneous lupus may include a variety of different looking skin rashes, photosensitivity (where exposure to ultra-violet light triggers a rash), and sometimes ulcers on the inside of the nose or mouth. There are a variety of ways that cutaneous lupus rashes can appear. The distinctive rash is called the "butterfly rash," which is a rash that extends across the cheeks of the face and the bridge of the nose.

Q. Does Isoniazid cause Lupus? I work in a Hospital and have been in contact with a patient who suffers from TB (tuberculosis). I was put under surveillance and now have to take Isoniazid in order to prevent developing TB. I read that this medicine can cause Lupus. Is this true?

A. Isoniazid can cause drug-induced lupus (DIL). However, there is a difference between DIL and systemic lupus. Systemic lupus is irreversible, whereas drug-induced lupus generally is reversible when the drug is discontinued. The symptoms of drug-induced lupus generally do not include kidney involvement or central nervous system involvement.