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lupus anticoagulant |
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anticoagulant /an·ti·co·ag·u·lant/ (-ko-ag´u-lant) acting to suppress, delay, or nullify blood coagulation, or an agent that does this. circulating anticoagulant a substance in the blood which inhibits normal blood clotting and may cause a hemorrhagic syndrome. lupus anticoagulant a circulating anticoagulant that inhibits the conversion of prothrombin to thrombin; it paradoxically increases the risk of thromboembolism and is seen in some cases of systemic lupus erythematosus. lupus anticoagulant, an antibody specific for phospho-lipoproteins or phospholipid components of coagulation factors, found in patients with systemic lupus erythematosus. It causes an increase in partial thromboplastin time and is associated with arterial and venous thrombosis, fetal loss, and thrombocytopenia. lupus anticoagulant Lupus inhibitor Lab Medicine Any IgG or IgM class antibody that arise spontaneously in Pts with SLE; while LAs produce in vitro interference with phospholipid-dependent coagulation–eg, activated partial
thromboplastin time–aPTT and kaolin clotting time assays in specimens from Pts with LE, they do not produce in vivo coagulopathy without other platelet or coagulation defects or drug-induced antibodies; LAs also occur in Pts with HIV,
DVT, and other conditions Lab ↑ aPTT; LAs interfere with derivative assays for factors VIII, IX, XI, and XII. See Systemic lupus erythematosus. Cf Anticardiolipin antibodies. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| Lupus anticoagulant is a term used to describe a phenomenon in aPTT testing that occurs when a patient's polyclonal antibodies influence the phospholipid-dependent reaction. Researchers have now identified two closely related lupus autoantibodies, anticardiolipin antibody and lupus anticoagulant (together called the antiphospholipid antibodies), that are associated with risk of miscarriage. Features of APS include hemolytic anemia, thrombocytopenia, venous and arterial occlusions, livedo reticularis, pulmonary manifestations, recurrent fetal loss, neurologic manifestations (stroke, transverse myelitis, Guillain-Barre syndrome); and a positive Coombs test, anticardiolipin antibodies, or lupus anticoagulant activity (1). |
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